ID A0A3Q1BYI2_AMPOC Unreviewed; 854 AA.
AC A0A3Q1BYI2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Extracellular calcium-sensing receptor {ECO:0000256|ARBA:ARBA00039746};
GN Name=CASR {ECO:0000313|Ensembl:ENSAOCP00000017994.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000017994.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000017994.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3Q1BYI2; -.
DR Ensembl; ENSAOCT00000032938.1; ENSAOCP00000017994.1; ENSAOCG00000002065.1.
DR GeneTree; ENSGT00940000157596; -.
DR OMA; KCPDDSW; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF358; EXTRACELLULAR CALCIUM-SENSING RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..854
FT /note="Extracellular calcium-sensing receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018761733"
FT TRANSMEM 597..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 597..840
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 854 AA; 96672 MW; 4D57BE2DA2DA31BC CRC64;
MRLLLYYVVL LGSSYVISTY GPHQRAQMTG DILLGGLFPI HFGVASKDQD LAARPESTQC
VRFNFRGFRW LQAMIFAIDE INNSSTLLPN ITLGYRIFDT CNTVSKALEA TLSFVAQNKI
DSLNLDEFCN CTDHIPSTIA VVGAAGSAVS TAVANLLGLF YIPQISYASS SRLLSNKNQY
KSFMRTIPTD EYQATAMADI IEHFQWNWVI AVASDDDYGR PGIEKFEKEM EERDICIHLN
ELISQYFEDH EIKALADRIE NSTAKVIVVF ASGPDIEPLI KEMVRRNITD RIWLASEAWA
SSSLIAKPEY LDVVAGTIGF ALKSGRIPSF KKFLQNVQPK KDSHNEFVRE FWEETFNCYL
EDSPRLQESE NGSTSFRPLC TGEEDITSVE TPYLDYTHLR ISYNVYVAVY SIAQALQDIL
TCTPGHGLFA NNSCADIKKM EAWQVLKQLR HLNYTNSMGE KMCFDENADL AANYTIVNWH
RSAEDGSVVF EEVGYYNMHV KRGAKLFIDK TKILWNGYSS EVPFSNCSED CEPGTRKGII
DSMPTCCFEC TECSDGEYSN HKDASVCTKC PNNSWSNGNH TFCFVKEIEF LSWTEPFGIA
LAICAVLGIV LTAFVMGVFV RFRNTPIVKA TNRELSYVLL FSLICCFSSS LIFIGEPQDW
TCRLRQPAFG ISFVLCISCI LVKTNRVLLV FEAKIPTSLH RKWWGLNLQF LLVFLCTFVQ
VMICVVWLYN APPSSYKNHD IDEIIFITCN EGSVMALGFL IGYTCLLAAI CFFFAFKSRK
LPENFTEAKF ITFSMLIFFI VWISFIPAYF STYGKFVSAV EVIAILASSF GMLACIFFNK
QQDQHVVYLN YRVD
//
