ID   A0A3Q1BYU0_AMPOC        Unreviewed;       628 AA.
AC   A0A3Q1BYU0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Unc-93 homolog B1, TLR signaling regulator {ECO:0000313|Ensembl:ENSAOCP00000013536.1};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000013536.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000013536.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the unc-93 family.
CC       {ECO:0000256|ARBA:ARBA00009172}.
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DR   AlphaFoldDB; A0A3Q1BYU0; -.
DR   STRING; 80972.ENSAOCP00000013536; -.
DR   Ensembl; ENSAOCT00000021645.1; ENSAOCP00000013536.1; ENSAOCG00000002488.1.
DR   GeneTree; ENSGT00530000063359; -.
DR   OMA; FWAPKPR; -.
DR   OrthoDB; 5315849at2759; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035325; F:Toll-like receptor binding; IEA:InterPro.
DR   GO; GO:0034121; P:regulation of toll-like receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR010291; Ion_channel_UNC-93.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR043268; UNC93B1.
DR   PANTHER; PTHR46744; PROTEIN UNC-93 HOMOLOG B1; 1.
DR   PANTHER; PTHR46744:SF1; PROTEIN UNC-93 HOMOLOG B1; 1.
DR   Pfam; PF05978; UNC-93; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        68..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        169..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        349..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        382..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        436..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        476..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        502..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          547..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        555..578
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        579..628
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  71529 MW;  C7700EBF25B93CD4 CRC64;
     MMEATDGEDL IRDADPLIVP PNGGMNELLN VGQEDNMQGQ MDEFLGPQAE YNEEEEERKY
     YRRKRLGVIK NVLAASFGAM IVYSVYMGLL QMQLILHYDM TYREVKYSNL GLQDIDRKML
     MGINVTPIIG LLYTPVLIRF LGTKWMMFLA SGIYALFVST NYWERYYTLV PSAVAIGVAI
     VPLWASLGNY ITRMAQQYYE YANYKEEHVQ EQKKLPKGAC HSYIIVFQSV FNIIFSLSFI
     FAELPMRLVL NGYLRDSIHI LHNVKKCGAE ISGVIPGFNT TVLTNLPRSM LLIQVESVLM
     GFAFLAMIIF LVLCGPAYRP TEEIDLRSIG WGNIFQLPFK HLRDYRLRLL CPFFVYSGFE
     VLFAIKGFSL SYGVCGLGLD KLWLLIVVYG LSCSVFSTLS LCLLRLPRWV CLVGGAAVHV
     ALLVALMVFS PEPKNASYGP LLVISVLWGL GTALNKTGVS TLLGILYAEE KERLDFVYTI
     YHWFQAIAIF IVYLWSNLPM RAKLSILLAT VLLACYCYWV MERRLAGKVP YRLPRIPRPR
     HKVKGYRYLE EDNSDESESE KSEEDDEEDE EENEDGVVEE MGAEGREDGG QDGGAESPRA
     RRRGVEGHWQ RREGNHVREG EREERKGG
//