ID A0A3Q1BZ43_AMPOC Unreviewed; 3009 AA.
AC A0A3Q1BZ43;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513, ECO:0000256|RuleBase:RU365027};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513, ECO:0000256|RuleBase:RU365027};
GN Name=ATM {ECO:0000313|Ensembl:ENSAOCP00000019655.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000019655.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000019655.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|RuleBase:RU365027};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365027}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769, ECO:0000256|RuleBase:RU365027}.
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DR STRING; 80972.ENSAOCP00000019655; -.
DR Ensembl; ENSAOCT00000015052.1; ENSAOCP00000019655.1; ENSAOCG00000003225.1.
DR GeneTree; ENSGT00670000098061; -.
DR OMA; VVTKGCC; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:Ensembl.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR InterPro; IPR021668; TAN.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF11640; TAN; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01342; TAN; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365027};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU365027};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU365027};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365027};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365027};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU365027};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365027}.
FT DOMAIN 1883..2524
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2638..2955
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2977..3009
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 3009 AA; 339761 MW; 8AD6F4B1252CE0EE CRC64;
MSLALNDLLL CCRGLENDKA TERKKEAEHF RRLLRSPETV QELDRTSGPK AKGSKQLTWD
TVFRFLQRYV QKETENMQSS KANVTATTLA MRQKKMAEIC SLVKYFIRYA NKRGPRLKCS
ELLKHVMEVL QNSYCCSAYG ENYSNLLIKD ILSVRKYWCD ITPQQWHSLL DLYCGLFSSS
SKSINRVLVS RVIHTVVQGC CMQTDGFNNA LFSFFSKALL NRHLTVLEHL VSALNVFLRS
AAMNCRMRVC GLGEELLPTI LYIWADMRPS TTLKKEIVGF FNLQICVHHP NGAKTQDTGA
HAEDWTKWQS LLYNLYDALV REISHIGSRG KYVTGTRHIA VKDNLIELTA DICRQLFNDD
SDTHVLEVTQ ASLRATQMGS PTHGAASKRR RIEIGWEVLR DHLQPQHNDF DIIPWLQITA
VLASKYPSMV PGKELVPLLS VLHQLLAEQR RGERGLYVLR CLREVARCQA HDPHKAQAFR
AELCRLWVRV WALAVRGVSS PQTESLSLDL LASIVHGGLI HMDREFWKIF SGSACKPSHF
VNALLKCPVP KSLSSSSSWD YMGVTEGAAA PNLKEILIAW LLMSDQSDEM EESSRPHPIV
CRDFPDNLTA NILVSLTLKD TRVGLKFLAF YQDQSPSDAK DNLEEVEGLY QQFSFNTLPS
EVQRADESLK TPSADCQFAA VPGLRQKLEQ SLLCVADNLL NCYSPDSQST PPECLVRCFS
QLTGVLAAYV STGFLTEEQA HRSQLFTKAK ALAQDFSGFV SSVKVKMTEE GTMTTLRSVM
KLCTQSASRK NKDNISPAAS ALFIMILPAS LLSELAEICK LLVMKNKPFF CPLTGAKSLL
ADDYLAQQDL ALLAVLEFLC ECGSVQPFHG LLFKPQEVRR RLLLLVEQID FSKALHLNLY
LILLKKLPAE DSLSPEEFDS LLRPLADLCS LYRQDQDVCA AVLLSLLPSI KSLGKTHHMP
EEMRHVQGSL LQVVSGFCYL SQTGKCVAAV RAALVHCLVA LLEADPRCNW ATLSVRGQER
EEDSPVSTIL PSHLADAHHQ VRMLVAMSVE RYASKRKMLP LKHQQAAFEN IYLKAQEGMK
LPRSSSSEDQ QDETFNRKAT LLKSLSVVLC CSPVCEKQSL FALFQSYKEN NIEEQLIKKV
NKIVSSALGY RSVKTFVSSH LYYLVAEWLS QRQSDDRYTL GSFPYSLLDN DTVKDFYNSS
YQVLIPHLVF LDDFEQVKSI GRCLEKDWRE LLADCFPRIM VNILPSFALP GQESRVAEQR
EKAHRVYDLL KDASCLGKQQ IDNLIHSNLA DIVVELLMTL YEGSGAERDR GDLTRFIGEL
DPVPNPPYFS SYVIKATLDY LSKCHSANHK SLVAILSKTP ISIQRILLAV CEKAAETTNS
YERHRILLMY HLFVSLLLRE VKDGLGGAWA FVLRDIIYTL IHHLNSRPLQ CDEVSNRSLS
LCCDLLTSVC QAALQFCDDA LDCHLQVIIG TLTAQVTSRP SISQQVLSLL HFLVIENQQK
LKGAISRLEP FPDIPEFREL RSVQHKLKYN SGTFTLRQEI DHFLSVTSCD SLPLTRLEGL
KDLTRQLHDN KGQIRELLKE CQGDPTDSVL VKLVLSLLRL CKLAANHPGG ADILEVAGSC
LGELGPVDFS TIALLHGRDP LYEKAVSLFT STESQCLYII LNCMNDALTH IEVRRAAAQC
VKNILATQSG VDFWDQHKDN RDPMLAYLNP FRTAKSKEST EAKGKLEGQE FWIPQMGGHK
AWLKALCTAL LDSGGVRSEA LLLSRPLCLV RVDCCQRLLP LIIHSILLDD SDGSWRKFLS
SHIQDFFTFC SRSAQASSRS ATPLNSDSES DTASPGLYDK TSLRTMLAVI DYLRHQQRPV
EADSNSCGTV CDSNFWLELN YLEVAKAAQS CSAHFTALLY TEIYVDNIKT NMEESRRTKS
KATRKISFED NSQNFTISSL TEKSMEDTSI SLQELLIEVY RSIGEPDSLY GCGGETMTSP
LTRIRTYEHE AMWGKALSSY DLHSTLPEVI RQVGIVEGLQ NFGLSSILTT YMRGLEAEGV
EWGAELRDLR FQAAWRNTQW DCELSERSEK SNPGFHESVF CGLQALRDKE FSIFDETLKL
ARGAEVEELC RGSLEAVSSL YPALRNLQSI RELQSVKQLF SRPFSDVALR EVCSQWRQHS
QLLTDSDFAL VEPILAVRSV AQHTLLSRAG DPDSTEYISS MLTDHLMELC CLARKAGNTQ
LAERAVYQMK QNGSGGTWVS SPVSSLQLEE AQVFWVKGEQ GLALGLLRQM IHNLEEKVHL
NPALTPVYTE CLRLCGNWLA ETCLESPGVI LENYLERAVE VIEGESGVQD SRLQSQRTKA
FLSLARFSDA QYQSIIKYMN SSEFENKQAL LVKAKEEVDL IKERNVPPNR YTRKVKQELE
LDEKALSNLQ TDRQRFLCKA VENYIQCLEQ GEEHDTWVFR LASLWLENAD IKVVNDMMKK
GVKLIPSYKF LPLMYQLAAR MGTKMAAGVA EDTGFHDVLF DLIFRASLEH PHHTLFIIFA
LVNANKDEKF CRSRLSKSAP PQQSPFDLER SDVAWKIISA IRKKKGEMIR GIERLCDAYI
TLAYMDASRH KTEKKAIPIP ADQPIMQIKD LDEVAIPTME IKVDPSGCYD NLVTFRSFLP
HYHLAGGINL PKIIDCVGSD GKSRRQLVKG QDDLRQDAVM QQVFSMCSML LQRNTDTRKR
KLNIRRYKVV PFSQRSGVLE WCSGTVPIGE FLVDPNKGAH KRFRPQDWTN LACRRRMMEA
VKLAFDEKLQ AYSEVCKKFR PVFRYFCMER FLDPAVWMEK RLAYTRSVAT SSIVGYIVGL
GDRHIQNILI DEQTAELVHI DLGVAFEQGK ILPTPETVPF RLSRDIVDGM GITGVEGVFR
RCCEKTMEVM RSSQEALLTI VEVLLYDPLF DWTMNPLKAF YLQHDEQQEL NATLNSTMGG
DEIDNHRKSS DSQSFNKVAE RVLLRLQEKL KGVEEGTVLS VGGQVNLLIQ QAMDPKNLSR
LFPGWQAWV
//
