ID A0A3Q1BZG4_AMPOC Unreviewed; 579 AA.
AC A0A3Q1BZG4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000018394.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000018394.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR AlphaFoldDB; A0A3Q1BZG4; -.
DR Ensembl; ENSAOCT00000027967.1; ENSAOCP00000018394.1; ENSAOCG00000023785.1.
DR GeneTree; ENSGT00390000010463; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR HAMAP; MF_00313; Glutaminase; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR NCBIfam; TIGR03814; Gln_ase; 1.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF49; GLUTAMINASE KIDNEY ISOFORM, MITOCHONDRIAL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 62..143
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
FT REPEAT 498..520
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 559..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 64595 MW; 5BDDAEE0B336EDB5 CRC64;
MFTHCFSLQY KSFLFSLCCS SPPCFHLSRP HCRVVVLTFL PVCLCICVSC RRRKAGILPS
LEDLLFYTIA EGQEKIPAHK FTTALKATGL RTGDPRLKEC MEMLKVTLKT TSDGALDRHL
FKKCVQSNIV LLTQAFRKKF VIPDFQPFCA HIDELYDNAK NLSGGQVADY IPQLARFSPD
LWAVALCTVD GQRHTVGDTK VPFCLQSCVK PLKYAIAVHD HGTEYVHRFI GKEPSGLRFN
KLFLNEDDKP HNPMVNAGAI VCTSLIKVGC VMNFMNKMAG NEYVGFSNAT FQSERESGDR
NFAIGYYLKE KKCFPEGTDM TSILDFYFQL CSIEVTCESA SVMAATLANG GFCPITGERV
LSPEAVRNTL SLMHSCGMYD FSGQFAFHVG LPAKSGVAGG ILLVVPNVMG IMCWSPPLDK
LGNSVRGIQF CTDLVSLCNF HNYDNLRHFA KKLDPRREGG DQRVKSVINL LFAAYTGDVS
ALRRFALSSM DMEQRDYDSR TALHVAAAEG HGEVVRFLLE ACKVNPVPRD RWGNTPMDEA
VHFGHHDVVT ILRDYHNKYS PQDSSDDKQN AEKNLDGML
//
