ID A0A3Q1C1G6_AMPOC Unreviewed; 1517 AA.
AC A0A3Q1C1G6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DNA topoisomerase II binding protein 1 {ECO:0000313|Ensembl:ENSAOCP00000021052.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000021052.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000021052.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 80972.ENSAOCP00000021052; -.
DR Ensembl; ENSAOCT00000011505.1; ENSAOCP00000021052.1; ENSAOCG00000005530.1.
DR GeneTree; ENSGT00940000157001; -.
DR OMA; NVHCLKT; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:1902165; P:regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR CDD; cd17737; BRCT_TopBP1_rpt1; 1.
DR CDD; cd17731; BRCT_TopBP1_rpt2_like; 1.
DR CDD; cd17718; BRCT_TopBP1_rpt3; 1.
DR CDD; cd17749; BRCT_TopBP1_rpt4; 1.
DR CDD; cd18434; BRCT_TopBP1_rpt5; 1.
DR CDD; cd17727; BRCT_TopBP1_rpt6; 1.
DR CDD; cd17738; BRCT_TopBP1_rpt7; 1.
DR CDD; cd17728; BRCT_TopBP1_rpt8; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 9.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR049542; TopBP1-like_BRCT0.
DR InterPro; IPR044737; TopBP1_BRCT_1.
DR PANTHER; PTHR13561; DNA REPLICATION REGULATOR DPB11-RELATED; 1.
DR PANTHER; PTHR13561:SF20; DNA TOPOISOMERASE 2-BINDING PROTEIN 1; 1.
DR Pfam; PF00533; BRCT; 4.
DR Pfam; PF12738; PTCB-BRCT; 2.
DR Pfam; PF21298; TopBP1_BRCT0; 1.
DR SMART; SM00292; BRCT; 8.
DR SUPFAM; SSF52113; BRCT domain; 6.
DR PROSITE; PS50172; BRCT; 7.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT DOMAIN 102..181
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 195..284
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 353..443
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 636..733
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 910..1001
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1278..1356
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1391..1488
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 286..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1092..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1229..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1046
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1074
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1199
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1517 AA; 167343 MW; 1D2D95BF5143C4C5 CRC64;
MSKGDKEGFI VKFVESKGLK TEYAVKAYEA ILELQSEKYL KRIEEDEVLR MDQKDKSLFV
FSSFTTPAFL HCKKLGCRMV SPLVVLYCLQ HQHCVPKAEK PVYNMAMADI TISCTSLDKA
TRAEVMDLVQ LMGGRVYLDL NVSVTHLIAG EVGSKKYLVA ASLGKPILLP TWVKACWEKS
QDSLFRYTDL PLEDYLCPVL RGCTVCVTGL SSTERKEVQR LCEQHGGSYT GQLKMNECTH
LIVSEPTGQK YECARKWNVY CVSLHWLFDS IEKGFCQDES RYTVERNASK TTRPHTSTPT
GTGHKEDGPS LLGLSHISVN ASMTINDTAV TNGTISRLET PDPIDSLDLT VCPADDVLDG
CKLYLCGLPG KKLEKLRRLV NAAGGLRFNQ PSEELTHVVM GDLDQGLKNF LSKATHRPHV
VTVQWLLDSF SKGSLLPETG YLHPDCLPPA LPAVSVPAHH TPSSRLSAGP PVASPSTPRQ
KRAEEDLLSQ YMDDDPTVVD MPPAAAESSS RKSFSTAAEP QPEPWGPNHT RGPEPNSTLQ
EASEAGLFFG KCFLFVGFGT EAEAQLSVLV TEHGGRVLIG RTRVVADYAV VPLLGCSVEA
TVDEVVTDTW LAMCVEKECI LQLSSNPLFT PVAVMDGRFP LKDCILSVSQ FTGAERESLV
ELAKHLGANV QDYFVRLANQ KKGMLASTHL VLHSPEGTKY QAAKKWRLPA VTMYWILEAA
RTGQRAAEER FLVDLPPSPE RDEESFVGGS QKPVMPPPAC SSPEIPLLGV QSGKAITPLD
LGRFQSKVFR SVLDEMKPKE DIRTPKQNQD GGRRNPLQKD SSLQLDTPSR FLSRDQLFRP
SFNVKDALGA LETPGGRSKP GEKVETPLTD VINRNLKVAL ANSARNASEM QEVSASPQLT
KTTEKEVPQK EAGPLAGVVI CVGKKLSKMQ GELNAIAASL GADFRWVCDD TVTHYIYQGR
VGDNTREYRG VKERGLHVVS QYWLQACAEE QRHVPESLYP FTYNPKMSLN LSQLPSNSQR
SPPLTRTQVK DVTEAKADKS EHNATVEAAA PRRVSDGSID RDEMNDTTEK SDISETLQMR
ENLQRQLQEI MSATKLTTGR RTSVRLSRMG SGGADSSPNT PDGSRVGRSN NRRTLEALRV
TREAAMDINT EPSQSEQIVW DDPTAREERA KLADNLQWPG SPSQHSEPFA PPPPPSAENG
PQFRDSMTDS ELVEMAACDV IDQHMGQRVL TPPSEEPEND FPTPKAPSIA FPLANPPVAP
EPQEERKEEK QIPRFQLSSL SPQERIDYSH LIEELGGVVL DKQSFDPSCS HIIVGTPLRN
EKYLAAMAAG KWILHRSYLE ACRSVGRFIQ EDEYEWGSSS ILDALPSITS QQKRLALAAM
RWRKALQRRS EHEGAFSGWT VMLNIDQSRE SGFRRLLQSG GAKVLPSPSP SSYKETTHLF
ADFSRLKPGD FRVDVSEATS QGVTCLKPEY IADYLMQEPT PPIELYHLAA EAPSEEAPGT
PSLPAAAAAA CIGRLEL
//
