ID A0A3Q1C250_AMPOC Unreviewed; 901 AA.
AC A0A3Q1C250;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A8 {ECO:0000313|Ensembl:ENSAOCP00000021312.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000021312.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000021312.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3Q1C250; -.
DR Ensembl; ENSAOCT00000010822.1; ENSAOCP00000021312.1; ENSAOCG00000006055.1.
DR GeneTree; ENSGT00940000157422; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF37; ELECTRONEUTRAL SODIUM BICARBONATE EXCHANGER 1; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 296..318
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 330..354
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 374..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 409..427
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 511..529
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 549..567
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 597..616
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 637..661
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 697..716
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 792..809
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 14..220
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 267..774
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 65..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 901 AA; 100484 MW; B5D6177C0F64119F CRC64;
RHANYSGLPV CVCVADMVLD HQEASHELDD SVRVRVREAL LKRHHHQNEK KKNLIPIVRS
ITEGARKQSE PHLTATSPQP PPPSEPAKNG AGQDSTQVDL SKVDMHFMKK IPEGAEASNV
LVGELDFLER PIVAFVRLSP AVLLTGLTEV PIPTRFLFIL LGPDGKAQQY HEIGRSMATI
MTDEIFHDVA YKAKDRSDLL AGIDEFLDQV TVLPPGEWDP SIRIEPPKNV PSQEKRKMPG
VPNGTACQVM EELHAEHHGP ELQRTGRLFG GLILDIKRKA PFYLSDFKDG LSLQCVASFL
FLYCACMSPV ITFGGLLGEA TEGRISAIES LLGASMTGVA YSLFAGQPLT ILGSTGPVLV
FEKILFKFCK DYDLSYLSLR TCIGLWTALL CLVLVATDAS SLVCYITRFT EEAFAALICL
IFIYEALEKL FHLGELYPFN AHSDLDKLTL AYCRCAEPDN PSNKTLELWS ERNITASAIP
WANLTVKECI SLQGHFVGTA CGHHGPYTPD VLFWSTILFF STFFMSAFLK QFKTSRYFPT
KVRSMISDFA VFLTIVFMVL LDFAIGVPSQ KLKVPSKFQP TRDDRGWLIN PIGRNPWWTV
LAASIPALLC TILIFMDQQI TAVIINRKEH KLLKGCGYHL DLLMVGVMLA VCSVMGLPWF
VAATVLSISH VNSLKLESES SAPGEQPRFL GIREQRLTGL VIFLLMGCSV FMTKALQFIP
MPVLYGVFLY MGASSLKGIQ FFDRLKLFGM PAKHQPDFIY LRHVPLRKVH LFTLTQLTCL
VLLWVIKTSP AAIVFPMMVL ALVFIRKLLD FCFSKRELSY LDDLMPDLTL LSLLLRCDPS
DINISDEMSK TTVWKSLNSN QKDTRPVAAK KARPHPVSSS PLPSGNFHST HCGHFFLVIV
T
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