ID A0A3Q1C363_AMPOC Unreviewed; 1811 AA.
AC A0A3Q1C363;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Disks large homolog 5-like {ECO:0000313|Ensembl:ENSAOCP00000014826.1};
GN Name=DLG5 {ECO:0000313|Ensembl:ENSAOCP00000014826.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000014826.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000014826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAOCT00000031612.1; ENSAOCP00000014826.1; ENSAOCG00000019649.1.
DR GeneTree; ENSGT00940000155303; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR CDD; cd00992; PDZ_signaling; 4.
DR CDD; cd11860; SH3_DLG5; 1.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR006907; DLG5_N.
DR InterPro; IPR035537; DLG5_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46360; DISKS LARGE HOMOLOG 5; 1.
DR PANTHER; PTHR46360:SF1; DISKS LARGE HOMOLOG 5; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF16610; dbPDZ_assoc; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF04822; Takusan; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..92
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 596..688
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 683..774
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1261..1340
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1394..1474
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1485..1553
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1667..1797
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 94..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 165..234
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 283..386
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 415..575
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 97..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1071
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1811 AA; 203639 MW; C78C32535580F34E CRC64;
MEPKHKELLE KCYQNLVESI TDADRVVDVL AHCGTLSQSE RYELGHNCSS NSEKVDLLLK
ILTSKDRDHF AEFCSALEAT HPHLHSVLLN GIGPVDHTTG TPGQASSPPP AHMESHQVNE
KMETVLFQLR HVTRERDDLR KRLALSSPGT TFDDCRPNSK AGHDYERLKL QCMKAMADLQ
SLQNQHSTTL KRCEEAVKKA DFYHTLHSRL ASEHTQLKEE LEAVRQDNIQ LVREHNHVKQ
ACEELRRLHD DDQREVADMR MLHQQVMREG SSDVLNKLYD TAVDKLEAMK SDYEALRKHY
NEKTANHNAD LSRLDQAEEE NHRLQKQLDM LLKQRDAAIH YQQQYSSSIR RFDNTQQELS
KATAQNKELQ REMDRLQSET TRLKTQQLKA AKDSEKYKEE RDSVISEYRL IMSERDQVIK
EVDRLQTGLE VAEAKLKNTS SERRVANEEL EALRQKQDCA TLDMERANKE IEMLRKQYEA
ISQELKEALQ EAEVAKCRRD WAFQERDKIV AERESIRTLC DNLRRERDRA VSDLADALRN
LDDMRKQKND ASRELKELKE KLEDQLEKEA RYRQLMAHSS HDSAIDTDSM EWETEVVELE
KHRVRIDMDL KALGFDIAEG VNDPYLPGDC GIFVTKVDKG SIAEGRLRVN DWLLKINDVD
LTNKDRTQVI KTVLSGEGVI NMVVRRRKSL GGRIITPIQI NLAGQKDSGI GLESGVFVAT
LAAGSPAARD CNLTVGDRLL AINGIALENK SLSECESLLR NCHSSLSISL MKFLPQSSSG
QSLFETLRDS EKTSRVQTCE VHTRNCRNSK HNCSTQTDIC SCDLGSREED TCKDTGDSLD
SSSSSAHSHH KPFSNSSLHS HSLSTSHSSS EPHPEFCYRR QDLHHRPFTF TPVISDCTSP
QAAVDQLQSS PVKASGGTWP RVIAGASIPE CTQLSIYKKP KQRKSIFDVN AFRRPETTPK
LDYMSLSQLP KHSPQSSLSE SAQTPPTPPA RSDSFRFKHR QQNSSASDST ITTGTPPASP
AQATSRQDDG EVGKQHYYTD APPGETKTNS KKPAEEEGSR HRTEVLEKKR YRPKSAPALR
RNVTPLHIPV PIGLAPCPAV TAVMRNPVYT AWSHEIQTNN CPPAPSSGIH PPQHQGRLSL
DLSHKRTGDM TETSCSQPPH STHSLPSSAR LSSSATLQFR AERIKIPPTR YPRSTGSDRG
SLSHSECSSP TPPMSPVNLE TSSFTSSQSQ SSISTQPRIS VSPAPVGDRR KDGPYLEEPR
NVTVQKGAEP LGISIVSGEN GGVFVSKVTA GSIAHQARLE YGDQLLEFNG INLRNANEQQ
ARLVIGQQCD TVTILAQYNP HMFQLGNHSR SGNQPTPRES GATTPDHHSN VDTLSEQDEG
TMTPPSKQTT PSRLVRLKRI HVELGVQICG GNLYGIFVES LDDDSPAKSA DGLLTGDLIL
EYNGISMKNK TKEDAYLELL KPAETITFKV QNRVDILAEI KESPGDGFFI RALYEKVAEV
EQDLSFKKDD ILYVEDTLPN GNFGYWMAWQ LDENAQKLEK GQIPSKYMMD QEFYRRHSMA
DMKDDNGTSK TLSAAARRSF FRRRLKHKRS GSKDGKDLTA LDAISTDSLP ITEDGVSLMY
QRVQKVECSS PRPVLVLGPL VEASKDMLVK EAPAKFCRCL PEIMKASQQA IERGVKDCVF
IDYKRRSGHF DVTTVASIKE ITEKDCHCLL DIAPHAIERL HSVHIYPIVI FIRYKNAKQI
KEQKDPLYLR DKLSQKHSKE QFEAAQKVEQ EYSRFFTGVV QGGSVSYICT QIMTIVEQEQ
SKVLWIPDGA P
//
