ID A0A3Q1C8U3_AMPOC Unreviewed; 1704 AA.
AC A0A3Q1C8U3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Signal induced proliferation associated 1 like 2 {ECO:0000313|Ensembl:ENSAOCP00000023105.1};
GN Name=SIPA1L2 {ECO:0000313|Ensembl:ENSAOCP00000023105.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000023105.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000023105.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAOCT00000006297.1; ENSAOCP00000023105.1; ENSAOCG00000009063.1.
DR GeneTree; ENSGT00940000157388; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF7; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT DOMAIN 606..823
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 961..1037
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 44..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1640..1688
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 394..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1392..1428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1704 AA; 187619 MW; BBF33F000220B905 CRC64;
MSILSPVTDN KSNLVGIVGG PEEYSRAMQS EELFSRKLKA LNGSMGPPTS GMQGKPDGAG
KTNGTPAMPK MGVRARVTEW PPRKDGWDGR PSPNYQSVIP IFQNGQQEHT VEILEPGETV
CLEMDYTDKY TLSDLLSHSP LKGLHPIRQR SNSDVTISDI DSEDIMDQNA VNPNTGASLH
REYGSTSSID RQGLGGDGFF TMLRGYRVDT LDHRSIPPLG FPELLRCDAP FSPSLQTAAQ
IARGEIVHIP GYDYIDSSLL YSREQEKSFM RRLKSESSET SLFRKLRTIK SESDALRLSI
EDDRRPLSFQ KCFAHYDVQS VLFNISEAVA SRANLSQRKN TTTGASAASA GIGPGASGVS
GGGAGAGPGA GADGGAAGCS SGNPPMFESP LGSREDLNPK ENLDVDEGDG KSNSLVLSCP
HFRNEIGGEG ERKISLSRAN SANYSGVSES CSFESSLSSH CTNAGVSVLE VPRENQPIHR
EKVKRYIIEH IDLGAYYYHK YFYGREHQNY FGVDDNLGPV AVSVRREKLD EGKEKEGMQY
NYRVTFRTSQ LTTLRGAILE DAIPSTARHG TARGLPLKEV LEYVIPELNI QCLRLALNSP
KVPEQLLKLD EQGLSFQHKV GVLYCKAGQS TEEEMYNNES AGPALEEFLD LLGQRVRLKG
FTKYRAQLDN KTDSTGTHSL YTTYKDYELM FHVSTMLPYT PNNRQQLLRK RHIGNDIVTI
VFQEPGALPF TPKHIRSHFQ HVFVIVKVHN PCTDNVCYSV AVSRSKDVPP FGPPIPKSVT
FPKSAVFRDF LLAKVINGEN AAHKSEKFRA MATRTRQEYL KDLAENFVST ATIDSAVKFS
FITLGAKKKE KVKPRKDAHL FSVGAITWSV CARDFGQSMD VYCLLGISNE FIVLIEEESK
NVVFNCSCRD VIGWTSGIMS IKIFYERGEC VMLSAHDNCG EDIREMVQRL EITTRGCETS
EMTLRRNGLG QLGFHVNFEG IVADVEPFGF AWKAGLRQGS RLVEICKVAV ATLTHEQMID
LLRTSVTVKV VIIQPHEDGT PRRGCSELYR IPMVEYKVDS EGTPCEYKTP FRRNTTWHRV
PTAAGPPLSR GSPTQGPDRL QCQQILQQHQ AAIPRSTSFD RKLPDGSRTM QDMENPQVTS
CNKGDQHYRS SPSNQSSSSD PGPCGSGTWS QQPGYDGCPS PILHERPGDM QGGDGEIHRE
REPTLERTRS AEAKWHIPST KILNPLKQRE GGKDSPNKLS RTGDKNSSHS SSNTLSSNAS
SNSDDKHFGS GDLMDPEMLG LTYIKGASTD SGIDTNPCVA PGARVLLQGR VGEQGQPWVS
EHHEDGTSEE DHGKLYLPQG YASAIMSSHV TEGSIGDLSE ISSHSSGSHH SGSPLARGAR
YCISADSSKV YTIPQTSSSG SEPGPGPESG PSSEACGQTR TQASCKLPVG MKTTDDDDDD
DDAHSTEGPP SISECGGAES LLAFLLQMLS ERSRQLYAQE AACRLQADGK SLQRLSKEEY
LKMMLPVSPP GEDRNRKVSA VGSLSPRRSL YRTLSDESVC SNRKGSSYAS SHSSMLDQAM
PNDILFSTTP PYHSTLPPRM IHNQGASNLR NQRVASFCTM TDMQRAEALQ ISRELTRRVV
EAEGAALEAD SSPSTLTGKV NQLEVILRQL QHDLRKEKED KAMLQEEVQH LRQDNMRLQE
ESQTAAAQLR KFTEWFFHTI DKKP
//
