ID A0A3Q1C8U9_AMPOC Unreviewed; 338 AA.
AC A0A3Q1C8U9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Tubulin folding cofactor C {ECO:0000313|Ensembl:ENSAOCP00000016626.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000016626.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000016626.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Supercomplex made of cofactors A to E. Cofactors A and D
CC function by capturing and stabilizing tubulin in a quasi-native
CC conformation. Cofactor E binds to the cofactor D-tubulin complex;
CC interaction with cofactor C then causes the release of tubulin
CC polypeptides that are committed to the native state.
CC {ECO:0000256|ARBA:ARBA00026055}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TBCC family.
CC {ECO:0000256|ARBA:ARBA00008848}.
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DR AlphaFoldDB; A0A3Q1C8U9; -.
DR STRING; 80972.ENSAOCP00000016626; -.
DR Ensembl; ENSAOCT00000025649.1; ENSAOCP00000016626.1; ENSAOCG00000021589.1.
DR GeneTree; ENSGT00940000162058; -.
DR OMA; YFQHEIT; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR Gene3D; 2.160.20.70; -; 1.
DR Gene3D; 1.20.58.1250; Tubulin Binding Cofactor C, N-terminal domain; 1.
DR InterPro; IPR017901; C-CAP_CF_C-like.
DR InterPro; IPR016098; CAP/MinC_C.
DR InterPro; IPR006599; CARP_motif.
DR InterPro; IPR027684; TBCC.
DR InterPro; IPR031925; TBCC_N.
DR InterPro; IPR038397; TBCC_N_sf.
DR InterPro; IPR012945; Tubulin-bd_cofactor_C_dom.
DR PANTHER; PTHR15139; TUBULIN FOLDING COFACTOR C; 1.
DR PANTHER; PTHR15139:SF0; TUBULIN-SPECIFIC CHAPERONE C; 1.
DR Pfam; PF07986; TBCC; 1.
DR Pfam; PF16752; TBCC_N; 1.
DR SMART; SM00673; CARP; 2.
DR PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT DOMAIN 160..314
FT /note="C-CAP/cofactor C-like"
FT /evidence="ECO:0000259|PROSITE:PS51329"
FT COILED 15..49
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 338 AA; 37699 MW; F974A9C2FC8F32A8 CRC64;
MSFVDTGVTG GSGAARLQER LQKRHQARIE DAERRREAKE SRSVAEEEVQ YFSRSFSRER
ADIEELLASC CGAERSLVTQ NLEEATDRTT QLQKFLNDSL MFLTQYELRQ AQAALQKLQT
SLTETREGAL PKKKFTFRAR TKAAGKVSAA GTPPPAAASP ADPGVMAVDG ASEQCGFSNV
RDELLIKTAE EIQKQDVLLT HLSNCRVRLI GSPSTLHLKN IDSCEILCGP VSSSVFIDQC
RNSTLAFPCQ QLRTHNTSDT QVYLHVTSRA IIEDCWGLSF APFSWSYPTL EEDFAVSGLD
RQRNNWREVD DFNWLAAGTP SPNWTVLPEA DRKTSWDS
//
