ID A0A3Q1CB65_AMPOC Unreviewed; 1590 AA.
AC A0A3Q1CB65;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=T-lymphoma invasion and metastasis-inducing protein 1-like {ECO:0000313|Ensembl:ENSAOCP00000024015.1};
GN Name=TIAM1 {ECO:0000313|Ensembl:ENSAOCP00000024015.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000024015.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000024015.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 80972.ENSAOCP00000024015; -.
DR Ensembl; ENSAOCT00000003881.1; ENSAOCP00000024015.1; ENSAOCG00000010587.1.
DR GeneTree; ENSGT00940000156294; -.
DR OMA; MQFYIPQ; -.
DR OrthoDB; 25601at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR PANTHER; PTHR46001:SF4; T-LYMPHOMA INVASION AND METASTASIS-INDUCING PROTEIN 1 ISOFORM X1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00455; RBD; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT DOMAIN 424..532
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 750..817
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 830..911
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1022..1216
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1442..1590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..41
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1461..1486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1511
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1590 AA; 178998 MW; 16EC8A26429E2605 CRC64;
MGNVESQNGD NALYGNGRGY LSRKHMSRSL RISNKQSRRS RHASSGKIEH RNSETSTRSS
STPSIPQSLA DNGLEPFNET NILPDFGSPI WVDRVAMNLR PVSFHNDLAS PSVHMNMMHI
TLPGPTAEEA QDEDVYTNEV KYLQKTRECS KETVSFKKRS KSADMWRDDS LEFSLSDVSQ
DHLTSTEEII DMGNERDFTD CEGHLQSSPT DSADRANSLD ELYSQTSPTR RQPHGRYAKW
HETNRAIREG EDDKMLSLSE EDGNTYGAYT LPCRRSHCLS EGLSSHQAAM CASMQGRRAQ
TIQDVTAGEG SEYEDSGIDG VTVEAEHQSR RYKTMSASFS VCSVHGRNMF AGSDSGSSSG
GGASECVQGV YENFRQELQM SSCQTESLEE AGSALSDEQS TMSSAYQSDL LLSVVQGMVR
KAGKLAVKNF LVHKKNKKVE SATRRKWKSY WVSLKGCTLF FYETDGRSGI DNNSIPKHAI
WVENSIVQAV PEHPKKDFVF CLSNSLGDAF LFQTCSQTEL ENWITAIHSA CATAVARQHH
REDTVRLLRA EIKKLEQKID MDEKMKKMGD MQLSAVTDTK KRKTILDQIF LWEQNLEQFH
MDLFRFRCYL ASLQGGELPN PKRLLAFASR PTKLAMGRLG IFSVSSFHAL VAARTETGVR
RRTQAMSRSC SKRKSRFSSL WGLDTTSKKK TKAHPPVSQV FADGEEPVKK PIDGIYVDPA
KEITKSEEGT VKILPRPSTE NDIWVPDHLT PSWVCLPNDQ PVLTIIQPGE SALCVLETIC
KAHQLDPTKH YLRLKFLIEN QVQFYIPKPE EDVCDLLYKE IELCSKITKV IQFDRDESCM
IGYGFSISVV EEDGVQQLYI TDVKAGGLAF AKGLNAGDEI LQLNGKDSHS LNFSDMKAAF
SQASLALTVN TLPSVDRRQL CYLPPRRSDA EEDLYTDIFS QSQEEILDDG VGLLLESSGD
SLDDDSEIFS EFDDCRKSTE QVAAFCRSLH DMNPVECVSS SPSPDSPFPP PATLRQLSDA
DKLRKVICEL VETERTYVKD LNCLIGRYLT PLQKETFLTQ DELDVLFGNL PEMVEFQVEF
LKTLEDGTRL VPDLEKLESV DQFKKILFSL GGSFLYYADR FKIYSAFCAS HTKVPKVLVK
AKTDPAFKAF LDERNPKQQH SSTLESYLIK PIQRVLKYPL LLKELYSLTD PDSEEHYHLD
VAMKAMNKVA SHINEMQKIH EEFGAVFDQL ITEQSSEKKE VADLSMGDLL LHNTVTWINP
PASLGKWKKE PQIATFVFKT AVVFVCKEGS KQKKKMGGSH RVSISSEEKD PFRFRHMIPT
DALQVRSLAN ADGEGSAVCE IVHTKSESEG RPERSFHLCC SSPESRKDFL KTVHSILREK
HRRQLLKTES LPLNQQYVPF GGKRLCALKG ARPAINRAAS APTRTLGRRK LVRNRFTIDT
DIVFDGEPEQ QDLASPQEPD LKRPQQEDEP DQHQQSELAG DTDRWVEEQF DLEEYEDQEE
MKETDILSDE DDELCQTPRA PSTEADLEDP IMALSLEGAE TEDDESIKSP GVSETPEDVK
PSDKEHQNQT EKDEIWVRRE QSGSPPESAT
//
