ID A0A3Q1CC89_AMPOC Unreviewed; 1152 AA.
AC A0A3Q1CC89;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO8 {ECO:0000313|Ensembl:ENSAOCP00000023009.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000023009.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000023009.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; A0A3Q1CC89; -.
DR STRING; 80972.ENSAOCP00000023009; -.
DR Ensembl; ENSAOCT00000006517.1; ENSAOCP00000023009.1; ENSAOCG00000008856.1.
DR GeneTree; ENSGT00940000157019; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF33; ANOCTAMIN; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 273..295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 307..324
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 379..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 462..485
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 262..895
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..743
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1080
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 128395 MW; C0899B5D4E8A6402 CRC64;
MPDTGTAAAA AGAAAAAATS GASAACDGPE SSRHRHRAQQ GDAERPDPGT APPQTSSGVL
DKLFGKRLLQ AGRHIMSHKS WMKTVPTENC DVLMTFADTT DDHTLLWLLN HIRLGIPELI
IQIRHHKHTR VYAFFVTATY ENLLRGAEEM GLRKAVKPEF GGGTRSFSCE EDYIYENIES
ELCFFTSQER QSIIKYWLDN LRAKHGEVLH NINFLEGQPI IPELSARGVI QQVFPLHEQR
ILSQLMKSWV QAVCEKQPLD DICDYFGVKI AMYFAWLGFY TTSMLYPAVI GFVLWMLTES
DQTSRDICCV VFALFNVVWA TLFLERWKRR GAELAYKWGT LDTPAESLEE PRPQFRGVKR
CSPVTGCEEF YYPPWRRRVF RWLVSLPICI LCLCFVFLVM LICFELQEFV MGIKEMPRLA
RFIPKIMLAI TVTACDEVYR KIACWLNDME NYRLQSAYEK NLIIKMVLFQ FVNSYLSLFY
IGFYLKDMER LKEMLATLLI IRQFLQNVKE VLQPYLYERH KLGELTLRAV WDLLLSVLLK
YARLAAGKAQ ASPTDQAMPG PGLRGTRPGL GQPERRDKKC LNGGCGVPDE EEGGERDEAD
SGRFSEGETE EESLIDCGLK LRKVSFIEKV DRRPAYPGPP MDHGFLEEGS PTMVEKGMDP
ASVFEMCDDD DDNGIHDVKD AAGGGTEGIN AASAAAAAGS AASLPSGSES STSLRHRRRG
RSAERVEAKT KRESWMDPPE ERESTTLTQA EMESCMQTYA DTFQDYQEMF VQFGYVVLFS
SAFPLAAMCA LINNIIEIRS DAFKLCTGLQ RPFGIRVESI GQWQTAMEAM GLIAIIVNCY
LIGQCGQLQR LFPWLSPEMA IISIVILEHF AILLKYVIHV AIPDIPTWVR EEMAKLDYQR
REAFKKHERQ AQQHYQQLQR RKREEEERQR QAEHMARRER ERDDSKGDSS GDHHHDKSHG
SKSRSGGGGG GSGSDKPKRP SSLLANNNVM KLKQIIPLQS KFSSGGARSP QSPTGSEPKL
PGFLSFKFLK SPENKKEGAA ASVATATATN TTATASSSSS SSLSGSSSQE RSQSPSKAFN
PGKLFNFGKS EGGTCVNGAP LPRSGEGSSS QTSERQPSRS DLNGVPDEIP SPGGEGSENG
HSTDLDPAGS KI
//
