ID A0A3Q1CEU1_AMPOC Unreviewed; 524 AA.
AC A0A3Q1CEU1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Sorting nexin 1 {ECO:0000313|Ensembl:ENSAOCP00000025420.1};
GN Name=SNX1 {ECO:0000313|Ensembl:ENSAOCP00000025420.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000025420.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000025420.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; A0A3Q1CEU1; -.
DR STRING; 80972.ENSAOCP00000025420; -.
DR Ensembl; ENSAOCT00000000271.1; ENSAOCP00000025420.1; ENSAOCG00000000814.1.
DR GeneTree; ENSGT00940000155889; -.
DR OMA; NHWGKVI; -.
DR OrthoDB; 1891044at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR005329; Sorting_nexin_N.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR10555; SORTING NEXIN; 1.
DR PANTHER; PTHR10555:SF129; SORTING NEXIN-1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF03700; Sorting_nexin; 1.
DR Pfam; PF09325; Vps5; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 145..274
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 58909 MW; BA59DE179894CB76 CRC64;
MAASSDRNPP PFPAAEDPEP GLVDPADGDS DEGEDIFVSK TNPVSVSRGV SQPDRGAEDP
PDLFSEEEEA SSTTAKSNGV HSDDDSDLFA EAHMELNTDK PGSSAKKELS ASSGPRSTST
STQSPAAMQP TSLEQLEEEE AKDSFDVDVA ITNPEKVGDG MNAYVAYKVS TRTSLTMFRS
KTFSVRRRFS DFLGLYEKLS VKQSLHGCII PLPPEKSVVG MTKVKVGMDD PSSVEFVERR
RAALERYLQR VVCHPSLLQD ADVREFLERD DLPRALNTQA LSGAGFLKMI NKASDAVNKM
TIKMNESDTW FEDKFQEVEA EEQQLRKLHA VVDSLVNHRK DLCGNTAVFA KSMAMLGNSE
DNTALSRALS QLAEVEDKME QLHQEQAASD FFIFAELLSD YIRLLGAVRG CFDQRMRAWQ
RWQEAQSTLQ KKREAEAKLL WANKPEKLQQ AKEDITEWES RVTQYERDFD RIGMTVRKEV
LRFEKEKAKD FKSQIMKYLE AMLQSQQRLI KFWEAFLPEA KAIA
//
