ID   A0A3Q1CFZ4_AMPOC        Unreviewed;      1150 AA.
AC   A0A3Q1CFZ4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Cartilage intermediate layer protein {ECO:0000313|Ensembl:ENSAOCP00000026647.1};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000026647.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000026647.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   AlphaFoldDB; A0A3Q1CFZ4; -.
DR   STRING; 80972.ENSAOCP00000026647; -.
DR   Ensembl; ENSAOCT00000018213.1; ENSAOCP00000026647.1; ENSAOCG00000015014.1.
DR   GeneTree; ENSGT00390000008152; -.
DR   OMA; RAETPYM; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR039675; CILP1/CILP2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR025155; WxxW_domain.
DR   PANTHER; PTHR15031:SF5; CARTILAGE INTERMEDIATE LAYER PROTEIN 1 ISOFORM X1; 1.
DR   PANTHER; PTHR15031; CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP; 1.
DR   Pfam; PF13927; Ig_3; 1.
DR   Pfam; PF13330; Mucin2_WxxW; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 1.
DR   SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..1150
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018613687"
FT   DOMAIN          275..364
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          1104..1150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1125..1139
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1150 AA;  128544 MW;  8B247D790D86502D CRC64;
     MLFGKTWAHL VGLVVILNYG RYAEHSKHKL PFRSYVLLYS ELCLDNYEWT TWFNVDHPGG
     RGDYEQLEAI RFYYRARVCE TPRAIEARTT EWVPARETGE TVHADPTVGF WCLNEEQSPG
     RNCSNYAVRF LCPKGLGAWG PWSDWSSCPA VCGQVGVQLR HRNCQSRSMP CSGPKVEGKA
     CNGPECPKID CSLHCVMGKV NADCDACMCE EHTLLGSVRS AGGLTAEGAT ILRSGKLLTL
     TDHNGHFRIP GICPDGNTTM TISLRGHTTL NVVVPSSTER TSVLSVHNPE SKTRREGKSA
     AFCCKVAGTP QPDKYQWFHN NSLMEKQSES TLVLKDLRSE QAGEYYCRAS GPSGAIKTKP
     ATLKILDEPS CNLKPESHLT RLPHDCYQNS TNSYYYDVGK CPSSTCAGQL DSGIRCKDKV
     AYCCGVAKME ERQLTCQGYQ LPTMVVTECG CQKCVDTKII VHGRAIAADN GEPMRFGHIF
     MNGVRISRTG YKGTFSIQVP PDTERLVLTF VDNMQKFVNT TKVLPFNPKG GAVYHEIKLL
     RKKAPVTISS TETNTLELGE VEGEEAMVEI EIPPHSFYKE NGEVFTGKVN ASVTFLDPRD
     VSTAAAAQSD LNFVGDEGDT LPLRTYGMFS VDFRGEENNE PLNAGEVKVF LDSAQVRMSE
     HLNTMKLWSL NPETGLWEEE GSLQVERKKR GKREERTFLI GNMEIRERRL FNLDVPENRR
     CYVKVRAFRS ERFMPSEQVE GVVVSLINME PTAGYSSNPR AWGRFDSVVT GPNGACLPAF
     CDEQKADAYS AYVMANLGGE ELEAVPSAPK LNPNLVGVPQ PYLGKLNYRR TDHEDPRVKK
     TAFSINVAKP SPNAAEESNG PVYAFENLKE CEEAPFSAAH FRFSRVEGDR YDYNTVPFNE
     DDPMSWTEDY LSWWPKPMEY RACYIKIKVN SPHEINVRSR NMGGTHPKTV GQLYGLRDTR
     SIRDMDQATV SAVCLEFKCS GMLYDQERVD RTLVKVIPQG SCKRDFVNAM LQEYLVNHLP
     LAVNNDTNEF TMLAPLDPLG HNYGIYTVTD QDPRTAKEIA LGRCFDGTSD GTSRVMKSNE
     GIALTFTCGD REVTRQSVFQ ALQGSQGQTV TSVVRGEGRQ NRRRQRANTP RNSRRRSTRN
     PAGRRAEARS
//