ID A0A3Q1CGN8_AMPOC Unreviewed; 910 AA.
AC A0A3Q1CGN8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Staphylococcal nuclease domain-containing protein {ECO:0000256|PIRNR:PIRNR017179};
DE EC=3.1.31.1 {ECO:0000256|PIRNR:PIRNR017179};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000026100.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000026100.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Endonuclease that mediates miRNA decay of both protein-free
CC and AGO2-loaded miRNAs. {ECO:0000256|PIRNR:PIRNR017179}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-
CC phosphooligonucleotide end-products.; EC=3.1.31.1;
CC Evidence={ECO:0000256|PIRNR:PIRNR017179};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR017179}.
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DR AlphaFoldDB; A0A3Q1CGN8; -.
DR STRING; 80972.ENSAOCP00000026100; -.
DR Ensembl; ENSAOCT00000016855.1; ENSAOCP00000026100.1; ENSAOCG00000014166.1.
DR GeneTree; ENSGT00510000047270; -.
DR OMA; EKTCCTV; -.
DR OrthoDB; 375531at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016442; C:RISC complex; IEA:UniProtKB-UniRule.
DR GO; GO:0016894; F:endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters; IEA:UniProtKB-EC.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:InterPro.
DR CDD; cd00175; SNc; 4.
DR CDD; cd20433; Tudor_TDRD11; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 5.
DR InterPro; IPR016685; Silence_cplx_Nase-comp_TudorSN.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047386; Tudor_TDRD11.
DR PANTHER; PTHR12302; EBNA2 BINDING PROTEIN P100; 1.
DR PANTHER; PTHR12302:SF2; STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00565; SNase; 4.
DR Pfam; PF00567; TUDOR; 1.
DR PIRSF; PIRSF017179; RISC-Tudor-SN; 1.
DR SMART; SM00318; SNc; 4.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF50199; Staphylococcal nuclease; 5.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50830; TNASE_3; 4.
DR PROSITE; PS50304; TUDOR; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR017179};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 17..166
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 193..327
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 340..496
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 525..660
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 729..787
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
SQ SEQUENCE 910 AA; 101945 MW; 68BF38D2960A3C2D CRC64;
MASVSAPSQT APAPTAPLQR GIVKMVLSGC AIIVRGQPRG GPPPERQINL SNIRAGAMAR
RAAQGQPDTK DTPDEPWAFQ AREFLRKKLI GKEVCFTVEI RTALGREYGM VYLGKDTTGE
NIAESLVNEG LATVRREGIR GNNPEQARLC ELEDQAKSSK KGMWSEGGGT HTIRDIKYTI
ENPRNFVDSL HQKPINAIIE HVRDGSVVRA LLLPDYYLVT VMLSGVKCPT FKREADVETP
EPFAAEAKFF TESRLLQRDV QIILESCPNQ IILGTILHPN GNITELLLKE GFARCVDWSM
AVYTQGAEKL RAAERSAKER KVRIWKDYVA PTANLDQKDR QFVAKVMQVV NADAMVVKLN
SGEYKTIHLS SIRPPRNEGE EKNKDKDKRF RPLYDIPYMF EAREFLRKKL IGKKVNVTVD
YIRAATGPGE GTPAFPERTC ATVTIGGINI AEALVSKGLA TVIRYRQDDD QRSSHYDELL
AAEARAIKNG KGLHSKKEVP IHRVADISGE TQKAKQFFPF LQRAGRSEAV VEYVFSGSRL
KLYMPKETCL ITFLLAGIEC PRSSRNLPGG MQVAEPFSDE AMLFTKELVL QREVEVEVES
MDKAGNFIGW LHIEGVNLSV ALVENALSKV HFTAERSAYY KTLVSAEDAC RQRKEKIWAN
YEEKPVEEVV HVSEEKERVA NYRPVYVTEI ADTLHFYTQD VETGGQLESL METMRAEIAA
QPPVEGSYSA RRGDYCIAKF ADGEWYRARV EKVESPAKVH VFYIDYGNRE VVSSTRLAAI
PPAFSTRTLP AQATEYAFAF IQVPQDEDAR ADVVDCVVRD IQNSQCLLNV EYSGATCPHV
TIQFGDTKDD VGLGLVKEGL VMVDVRKEKH LQKMVTEYLN SQESAKSARL NIWRYGDFRA
DDADEFGYSR
//