ID A0A3Q1CH78_AMPOC Unreviewed; 4146 AA.
AC A0A3Q1CH78;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Subcommissural organ spondin {ECO:0000313|Ensembl:ENSAOCP00000027082.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000027082.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000027082.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR STRING; 80972.ENSAOCP00000027082; -.
DR Ensembl; ENSAOCT00000018808.1; ENSAOCP00000027082.1; ENSAOCG00000015965.1.
DR GeneTree; ENSGT00940000155829; -.
DR OMA; QTKNELC; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 8.
DR CDD; cd19941; TIL; 9.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 23.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF401; INTESTINAL MUCIN-LIKE PROTEIN ISOFORM X1; 1.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF01826; TIL; 6.
DR Pfam; PF00090; TSP_1; 22.
DR Pfam; PF00094; VWD; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00832; C8; 3.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00209; TSP1; 23.
DR SMART; SM00214; VWC; 5.
DR SMART; SM00215; VWC_out; 8.
DR SMART; SM00216; VWD; 2.
DR SUPFAM; SSF57603; FnI-like domain; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF57567; Serine protease inhibitors; 7.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 23.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS50092; TSP1; 24.
DR PROSITE; PS51233; VWFD; 3.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2253..2278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..120
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 312..474
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 766..936
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT REGION 3195..3222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1119..1131
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1126..1144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1138..1153
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1162..1174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1169..1187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1207..1225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1285..1303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1297..1312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1367..1385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1379..1394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1737..1749
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1744..1762
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1756..1771
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1790..1802
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1797..1815
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1809..1824
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 4146 AA; 452300 MW; 5C1139ADB4CFA222 CRC64;
HRPPEMESQM VNKTVRTCCE GWGGPHCSEG ELTVMYGLVH WLGDFVFVES GLGVRVKFDL
GNTVYLTVTA EHLAATRGLC GVYNNDADDD FTTMGGTVSQ YAASFGNSWK VPDQHSEGCS
DAAELGHSCD VSGDPALRWQ AESVCHRLLE APFTHCYPRV DPAAYIDTCL YLYCSLPPRE
RKEAVCDTLA SYARECAQQH VILTWRTATF CGRVCPRGQV FSDCVSSCPP SCSSPQPPGP
AAVMGQCREE CVGGCECPPG LYLHQRLCLK RDDCPCFHRR RTYQPEDRIQ QRCNTCVCRA
GQWQCTGEKC AAQCTLMGAL QVTTFDRKRY SLQGGDCSFT AVEVRLNAVL YDMRCVCVSA
TLSLCSMCLI LLPPGAVTLN NQRETLPVVS GDLVVRRASS TFLLIQTFGA QILWYLEGPL
ALITLQPGFA NKVRGLCGTL TWNQHDDFTT PEGDVENSVS SFARKFTTER CTLPGGAPPE
PCSTYTQRRH YAETVCTIIH SPVFQGCHDV VEREPYFRLC LSEVCGCASQ TICHCTVLTA
YARHCAQEGV KVHWRNHTFC PVQCLGGQMY QECGRVCGGS CSDLRQGWTC DDSGGGISHR
MCVPGCQCPL GLVQDHQGQC VPIALCPCVQ GDKMYSPGTV VQNSCNTCVC EQGLFNCTQE
HCEEVNRCPG SLVYSPRSCL LTCSSLDPPG QQQASSVPQS SCREPLSGCV CPQGAVLLGD
RCVLPDECPC HHNGRLYYSN DTITKDCNTC VCKERRWHCS QSVCVGVCVA TGDPHYVTFD
GRCYSFLGDC QYVLARETSG LFSVTAENVP CGSTGVTCTK SVTLSLGNTV IHLLRGKAVT
VNGMPVTLPK SYSGSGLTLE KVGLFVSLSS RLGVTLLWDG GMRVYVRLAA HLRGRVGGLC
GNFDGDTEND FTTRQGIVES TAELFGNSWK VSPSCPDLNP HRVTWARKRC AVLTQEVFSL
CHPEVPFQQY YDWCVFDACG CDSGGDCECV CTAIAAYTEE CNRRGVYIRW RSQELCPLQC
ENGLVYDPCG PACSPSCPSV QQSPHSQCGA LSCVEGCFCP AGTVQHGDRC VAPTQCPCEW
EGSMFPPGTT ITQHCLNCTC EEGVWQCEGV ACPPPSLTCL ESEFTCAGGR CIPSQWVCDN
EDDCGDGSDE EFCGPATPRP LCPPGEFQCA NGKCLPTSHV CDGRLDCGFA DGSDEQGKDT
NNNTFACRGG TCVPTSKLCD GIPDCPGRED ENKTNCYTSI ITPSLPPVTP SSSNFITELF
IALTFPSLVS FLAYFLCSLY EKIKCSHAEC VPQAWRCDGE TDCMDGSDEQ QCAAPCGPGQ
VSCSSGDQCV DHQHLCDGTP HCRDASDEST DNCGSARIPP CPGSFSCDNR TCVNMSKVCN
GIPDCPRGDD ELVCPTDEQG CRPWSTWGPW SPCSTTCGTG SMNRRRSCPP GEPLRNCRGQ
DVQRQQCFNI TCPVDGEWLP WVSWSNCSSG CGGVQVRHRD CIPPRHGGRH CSQLAGPSNL
PMEIKPCPDD GCANSSCPTG LVRLSCAPCP LSCAHISSGT TCDPTAPCFS GCWCPKGQVM
SHTQQCVPPE ECACEVAGVR YWPGQQIKVD CEICVLHCGW SSWTEWGECL GPCGVQSVQW
SFRSPNNPTK LGDGRTCRGI YRKARRCQTH PCDECEYQGQ SHTVEDRWRS DHCQLCHCLP
SLTVQCSPYC PYAATGCPQV KGTVFEREAY LCIFKSLHFA PSITTSPHDG GLPRVLCVES
QFQCWSSGCV DSAQVCDGRP DCLDGSDEER CGTTVRPTVT PQRPLVPSRC SPKQFTCDSG
DCIHLDRRCD LQKDCVDGSD ERDCVDCIMS PWTAWSACSV SCGLGSLFRQ RDIIREALPE
GACGGAQFDS RACFDKACPV HGLWSEWTEW SKCDAQCGGG VRQRNRTCSA PPPKNNGRDC
EGLTRQSQSC NNQPCTKETG TQTGDGCRCP YGLYLQEGRC VNSSHCVCNL DGQILQPGQV
ISRDRCTTCM CRDGQVTCNT SSCVASCHWS VWSSWSPCDV TCGLGLQQRY RSPVNPAEAV
RVQPCPGDSS EARQCSSPCV PDGVWSKWTS WSECSKTCFN HVDDVGSKQR FRTCNHTLPL
SNHTDCSCVL PVHGGWSAWS LWTECSSQCD SGVQTRERFC SSPAPQHGGN SCTGPHIQTR
DCNSHPCSGT GVCPEGMMYL AAAECEAQGG ACPRVCLDMT SAEVQCATAC YDGCYCALGF
YLLNGSCVPL EQCPCYHQGA TYPAGATLLV DSFLYVSFFL VCTFFLCLNH LYFLLYVLVD
CGWSSWTQWS ACSRTCDVGV RRRYRSGTNP PPAFDGHPCK GDRVEIDTCS IEPCIGEKYL
PWSAWSECSV TCGGGYRTRT RGPIRIHGTC LYVLFHLIVS HQICLVSFVA DGQWSLWTPW
GQCSLTCGLG LQSRYRFCSS PQRVGSGPPC DGGWGQWSSW TACSKSCGGG VQSRRRACDS
PGPEGEGDYC EGLGTEVKAC NTDHCPVAPC SQVPGTVFSS CGPSCPRSCD DLAHCEWRCE
PGCYCTEARV LSANGTVCVE RVDCPCLDLN TGQRLEPGET TEAPDGCNNC TCEGGRLNCT
RDPCPVPGGW CEWSEWTPCS RTCGAESMSR YRSCGCPEPR AGGELCPGEQ EIHNRIGVQL
QRQPCPVMTF CPVHGSWSSW SAWLECDGCA GSSTRTRECN SPPARFGGLP CLGEGRQSRG
CHDNITVCSD CGGGQEEWTC GKPCPRSCSD LHGDTECLDS PGCSWTCGCP GDKVLQDGVC
VDREECRCRY HNSSATGSVH FLFMCKFVMD SCEAGVLRCL SFPGCHVDGG WSQWGWSGCS
VSCGGGQQSR SRFCSSPPCS GFSQQSKTCN THVCLDVGCP PGRLYRECER GEGCPFSCAQ
VSGRDGCYTD GCEEGCHCPP QTYQHHGVFY AICVFQECPC FVDEELLTSL QSVSVTPVSS
LFFHNISEGT ELQSGDTFVH DCSTCTCEHG RWNCSLDHCP VDGGLSAWSS WSPCSLSCGG
LGLKTRSRGC TNPTPAHGGR DCQGPRQETT YCQAPDCPGT GLNLQKEPTL PDEDSGFSLW
SLWSPCTKTC TDTLNPAMKS RHRRCISPPC SGSSHQEKAC NLPQCSGMVC LGDNCARRNC
SWTEWGVWGS CSRSCGVGQQ QRIRTFLIPG TNGSWCEDIL GGNLEHRFCN IRPCRVDGGW
SHWSPWSRCD KRCGGGRSIR TRSCSSPPSK NGGKKCEGEK NQVKPCNTKP CDEKGCPMGQ
EFVLCANQCP QRCSDLQQGI ECQGNNKCQP GCRCPEGELQ QDGVCVQLWQ CDCVDSLGQV
WAAGSWHQVD CNNCSCTDGQ LLCTNHSCQP TCVWSSWSSW APCSISCGEG QRTRYRSLIP
ETEGLDCHFE EVQHKPCKPG PCPPLCLLDN QDLSVGDTWL QGECEQCTCT PEGVYCQDID
CRVDGGWTPW SVWSDCSVTC GRGSHVRTRA CINPPPRNNG SHCSGPERET QTCWTSPLAP
RVSHWNTNRV DVSERSYMHN SVHGDAIHEY HYLMSPPPFV ACEAPFVYLA CGAPCEKQCS
LWRHEDLCSG VQECMPGCYC PQIADSVRHI VIIICLFPFL SFSVCHDGTL QSPSPCCPVS
LLMFSVILSE WSEWTPCSPC VPSSSLQHNS SAAGFLHDTN MVSIQRRFRA CLDLDSGLPI
TREEESQCPG LLVEERLCPD ANICRDLCHW SVWSSWTVCA EPCSGGVRQR FRQPLASPVG
PRCRSQQTQS QSCNTGLCPG ERCEDRGRSY QESCANQCPR SCADLWEHVQ CLQGSCHPGC
RCPEGQLLQD SRCVPVAECR CGIPSGNGTL EFIPEEELTM DCNTCVCENG SLVCTKLPCP
VYEPWSPWNS CSASCGPGQK TRTRHCQDTE GGPSCAETTQ TESCDLPSCP ECPSRQVFSD
CSASCPYTCQ DLWLHTQCLP GPCTPGCTCP SGQVCTPPCV CVCVCVCVCV CGVAFPISER
LHDLTYIGAL ICVPVEEMSH AEGQCHCALC KELSLVSVCH FSPSFHACTK NVCFYFHIFN
FPCLLFSVLL TPISLLPRLP SGEPEPECHR HVQLRNITKG DCWLDNVEVS FCRGRCLSRT
DVILEEPYLQ SMCECCSYRL DPDNPVRFLS LQCESGDSEP VVLPVIHSCE NIFMINFSKH
IFSVYL
//
