ID   A0A3Q1CLD5_AMPOC        Unreviewed;       709 AA.
AC   A0A3Q1CLD5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Engulfment and cell motility 2 {ECO:0000313|Ensembl:ENSAOCP00000028667.1};
GN   Name=ELMO2 {ECO:0000313|Ensembl:ENSAOCP00000028667.1};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000028667.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000028667.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC       phagocytosis of apoptotic cells and cell motility. Acts in association
CC       with DOCK1 and CRK. Was initially proposed to be required in complex
CC       with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC       nucleotide exchange factor (GEF) activity of DOCK1.
CC       {ECO:0000256|ARBA:ARBA00024863}.
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DR   AlphaFoldDB; A0A3Q1CLD5; -.
DR   Ensembl; ENSAOCT00000021991.1; ENSAOCP00000028667.1; ENSAOCG00000018482.1.
DR   GeneTree; ENSGT00940000159236; -.
DR   OMA; XDMANAF; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR   CDD; cd13359; PH_ELMO1_CED-12; 1.
DR   Gene3D; 6.10.250.810; -; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024574; ELMO_ARM.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR   PANTHER; PTHR12771:SF8; ENGULFMENT AND CELL MOTILITY PROTEIN 2; 1.
DR   Pfam; PF11841; ELMO_ARM; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   Pfam; PF16457; PH_12; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT   DOMAIN          305..474
FT                   /note="ELMO"
FT                   /evidence="ECO:0000259|PROSITE:PS51335"
SQ   SEQUENCE   709 AA;  81274 MW;  700EF76BB3E5578D CRC64;
     MPPPADIVKV AIEWPGANAQ LIEMDQVSRI FSPFLFCSWS LSGSEQFALR YADGPQLYIT
     EQSRGDIKNG TILRLAISPG RAARQLLERI QSHGIDARLE ALKELAKLSA DPTFATEFIN
     MEGIGTLARL VESGTHFGEM LAFTLTAFLE LMDHGIVSWD LISLSFIKQI AGYVNQPMVD
     VSILQRSLAI LESMVLNSHS LYHRVAQEIT VGQLIGHLQV SNQEIQTYAI ALINALFLKA
     PEDRRQEMAS TLAQKHLRSI ILNHVIRGNR PIKAEMAHQL YVLQVLTFNL LEERMMTKMD
     PNDQAQRDII FELRRIAFDG ENDPTGTEKR KAMYTKDYKM LGFTNHVNPA MDFTQTPPGM
     LALDNMLYLA KVHQDTYIRI VLENSSREDK HECPFGRCAI ELTRMLCEIL QVGELPNEGC
     NDYHPMFFTH DRAWEEFFCV CIQLLNKTWK EMRATAEDFN KVMQVVREQI TRALAMKPSS
     IDQLKNKLRG LNYSEILRLR QSERMSQDDF QSPPIIELRE RIQPEILELI KQQRLNRLCE
     GSCFRKLGNR RRQEKFWFCR LSLNHKVLHY GDLDESPQGE VPFELLSDKI PVSDIKSVVT
     GKDCPHMKEK SALKQNKEVL ELAFSVLYDP DETLNFVAPN KYEYCIWTDG LCALLGREMG
     SDLTRSDLDT LISMEMKLRL LDLENITIPE APPPVPKEPS SYNFTYNYS
//