ID A0A3Q1CP49_AMPOC Unreviewed; 706 AA.
AC A0A3Q1CP49;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cullin 2 {ECO:0000313|Ensembl:ENSAOCP00000027553.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000027553.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000027553.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR AlphaFoldDB; A0A3Q1CP49; -.
DR Ensembl; ENSAOCT00000030513.1; ENSAOCP00000027553.1; ENSAOCG00000016605.1.
DR GeneTree; ENSGT00940000154926; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF177; CULLIN-2; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 386..618
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 706 AA; 82370 MW; 27981B94820F93B5 CRC64;
MSLKPRVVDF DETWNKLLTT IKAVVMLDYV ERATWNDRFS DIYALCVAYP EPLGERLYTE
TKVFLENHVR QLYKKVLDSE EKVLVMYHRY WDEYSKGADY MDCLYRYLNT QFIKKNKLTE
ADLQYGYGGV DMNEPLMEIG ELALDMWRKL MIEPLQAVLI RMLLNEIKND RCGENPNQKV
IHGVINSFVH VEQYKKKFPL KFYQEIFEGP FLTKTGEYYK QEASNLLQES NCSQYMEKVL
ARLKDEEVRC RKYLHPSSYA KVIHECQQRM VADHLQFLHG ECQSIIRQEK REDMANMYTL
LRAVSNGLPH MIQELQVHIH NEGIRGTSNL SQENMPTLFV ESVLEVHSKF VQLINTVLNG
DQHFMSALDK ALTSVVNFRE PKSICKAPEL LAKYCDNLLK KSAKGMTENE VEDKLTSFIT
VFKYIDDKDI FQKFYARMLA KRLIHGLSLS MDSEEAMINK LKQACGYEFT SKLHRMYTDM
SVSADLNNKF NNFIKTQETV VDLGISFQIY VLQAGAWPLT HVPSSTFAIP QELEKSVQMF
ELFYNQHFSG RKLTWLHYLC TGEVKMNYLS KPYVAMVTTY QMAVLLAFNN SQTVTYKELQ
DGTQMNEKEL QKTIKSLLDV KMLNHDSQKE EIEVESTFSL NMSFTSKRTK FKITTSMQKD
TPQVINQSKA RFNPSISMIK KCIEVLIDKQ YIERSQTSAD EYSYVA
//
