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Database: UniProt
Entry: A0A3Q1CQ69_AMPOC
LinkDB: A0A3Q1CQ69_AMPOC
Original site: A0A3Q1CQ69_AMPOC 
ID   A0A3Q1CQ69_AMPOC        Unreviewed;       794 AA.
AC   A0A3Q1CQ69;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184, ECO:0000256|PIRNR:PIRNR003048};
DE            EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184, ECO:0000256|PIRNR:PIRNR003048};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000027604.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000027604.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-
CC         lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752,
CC         Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC         Evidence={ECO:0000256|PIRNR:PIRNR003048};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR003048}.
CC   -!- SIMILARITY: Belongs to the acetyltransferase family. GCN5 subfamily.
CC       {ECO:0000256|ARBA:ARBA00008607, ECO:0000256|PIRNR:PIRNR003048}.
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DR   AlphaFoldDB; A0A3Q1CQ69; -.
DR   STRING; 80972.ENSAOCP00000027604; -.
DR   Ensembl; ENSAOCT00000030549.1; ENSAOCP00000027604.1; ENSAOCG00000016687.1.
DR   GeneTree; ENSGT00940000158799; -.
DR   OMA; ERYFQTK; -.
DR   OrthoDB; 1760108at2759; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd05509; Bromo_gcn5_like; 1.
DR   CDD; cd04301; NAT_SF; 1.
DR   Gene3D; 3.40.630.30; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR037800; GCN5.
DR   InterPro; IPR016376; GCN5/PCAF.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR009464; PCAF_N.
DR   PANTHER; PTHR45750; GH11602P; 1.
DR   PANTHER; PTHR45750:SF1; HISTONE ACETYLTRANSFERASE KAT2A; 1.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF06466; PCAF_N; 1.
DR   PIRSF; PIRSF003048; Histone_acetylase_PCAF; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   SUPFAM; SSF47370; Bromodomain; 1.
DR   PROSITE; PS00633; BROMODOMAIN_1; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|PIRNR:PIRNR003048};
KW   Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW   ProRule:PRU00035}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR003048};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR003048};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PIRNR:PIRNR003048};
KW   Transferase {ECO:0000256|PIRNR:PIRNR003048}.
FT   DOMAIN          460..613
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS51186"
FT   DOMAIN          702..772
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        532
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR003048-1"
FT   BINDING         536..538
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR003048-2"
FT   BINDING         543..549
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR003048-2"
FT   BINDING         574..577
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR003048-2"
SQ   SEQUENCE   794 AA;  90641 MW;  C976053DA47CAFAB CRC64;
     MSDPAAQALQ PRLLQAQSAG SSTATTGSGS GNSDPSRPGL SQQQRASQKK AQVRAFPRAK
     KLEKLGVFSA CKASDTCKCN GWKNPNPPSA TRMDLQQQAA SLSEPCRSCG HALADHVSHL
     ENVSEEEINR LLGMVVDVEN LFMSVHKEED TDTKQVYFYL FKLLRKCILQ MSQPVVEGSL
     GSPPFEKPNI EQGVLNFVQY KFSHLAPKER QTMFELSKMF LLCLNYWKLE TPTQYRQRTQ
     KDDGTAYKVD YTRWLCYCHV PQSNDSLPRY ETTHVFGRNL LKSIFTVTRR QLLEKFRVEK
     DKLLPEKRTL ILTHFPKFLS MLEEEIYGEN SPIWEADFTM PASDGTQLGH QTVISPPSVS
     GSPALSKCLS SSSSLGSIDA GGVEPITGEK RKLPEVLTLE DAKRIRVMGD IPMELVNEVM
     MTITDPAAML GPETNLLTPN AARDETARLE ERRGIIEFHV IGNSLSQKSN KKILMWLVGL
     QNVFSHQLPR MPKEYITRLV FDPKHKTLAL IKDGRVIGGI CFRMFPTQGF TEIVFCAVTS
     NEQVKGYGTH LMNHLKEYHI KHNILYFLTY ADEYAIGYFK KQGFSKDIKV PKSRYLGYIK
     DYEGATLMEC ELNPRIPYTE LSHIIKRQKE IIKKLIERKQ SQIRKVYPGL TCFKEGVRQI
     PVESIPGIRE TGWKPSNKDK GKEVKDPDVL YNMLKNLLAQ IKTHPDAWPF MEPVKKSEAP
     DYYEIIRFPI DLKTMTERLK NRYYVTKKLF IADLQRIITN CREYNPPDSE YCKSANTLEK
     FFYFKLKDGG LIEK
//
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