ID   A0A3Q1CQC5_AMPOC        Unreviewed;       215 AA.
AC   A0A3Q1CQC5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Ciliary neurotrophic factor {ECO:0000256|ARBA:ARBA00015150};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000030177.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000030177.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: CNTF is a survival factor for various neuronal cell types.
CC       Seems to prevent the degeneration of motor axons after axotomy.
CC       {ECO:0000256|ARBA:ARBA00025427}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the CNTF family.
CC       {ECO:0000256|ARBA:ARBA00007988}.
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DR   AlphaFoldDB; A0A3Q1CQC5; -.
DR   STRING; 80972.ENSAOCP00000030177; -.
DR   Ensembl; ENSAOCT00000032151.1; ENSAOCP00000030177.1; ENSAOCG00000002441.1.
DR   GeneTree; ENSGT00420000029890; -.
DR   OMA; CVVLTTY; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; IEA:InterPro.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000151; Ciliary_neurotrophic_fac_CNTF.
DR   InterPro; IPR001581; Leukemia_IF/oncostatin.
DR   PANTHER; PTHR15196; CILIARY NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR15196:SF0; CILIARY NEUROTROPHIC FACTOR; 1.
DR   Pfam; PF01291; LIF_OSM; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           37..215
FT                   /note="Ciliary neurotrophic factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018662309"
SQ   SEQUENCE   215 AA;  24032 MW;  9AD062AA872053FD CRC64;
     MNGHVKSMSF QQFMESATTL LSLLLIMAVD STKTVAASRN QQCGNALLQT LKLTRLVRKE
     STDLIKTYKL YQGEMSDLFC EGSVNNIPDP SISGLDPSEK IVSIYTNLQM FIPHFKRVYE
     QQTDLQLPTS PLLTELTNVS LRSRNLALLI KTFYQSLFPN LPVPEPAGGP TTLPPPQNVF
     QQKVYGCVVL KTYKKFLLDV SKVLNNIKGT PIYGI
//