ID A0A3Q1CQN1_AMPOC Unreviewed; 924 AA.
AC A0A3Q1CQN1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Sodium/calcium exchanger 2-like {ECO:0000313|Ensembl:ENSAOCP00000030282.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000030282.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000030282.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR AlphaFoldDB; A0A3Q1CQN1; -.
DR STRING; 80972.ENSAOCP00000030282; -.
DR Ensembl; ENSAOCT00000025155.1; ENSAOCP00000030282.1; ENSAOCG00000021184.1.
DR GeneTree; ENSGT00940000158344; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF8; SODIUM_CALCIUM EXCHANGER 2; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..924
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018662828"
FT TRANSMEM 86..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 749..773
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 826..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 856..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..915
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 396..496
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 522..621
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 924 AA; 101838 MW; 3F36603358242095 CRC64;
MGLLHSHTSS LLFLLLSLLL LCHHCTSFGP EFVERASGPE QPQTSGNMTG SGKRTCSGVV
VCKPGILLPV WLPLNPPVAE QAGRAVVYFL CLIYMFLGVS IVADRFMASI EVITSQEKEV
TITKPNGETT VTTVRIWNET VSNLTLMALG SSAPEILLSV IEVCGHNFDA GELGPGTIVG
SAAFNMFVII GLCVWVIPDG ETRKIKHLRV FFITAFWSIF AYIWLYLILA VISPGIVEVW
EAAVTLLYFP VCVVLAWIAD RRLLIYKYMH KRYRADKRHG IVVEMEGDVD SKGIDVIMDG
KLSDGNSCPG NSSSVTVSVQ TGNELDQNKD EVVRILKDLK EKHPDKDLDQ LIEMANYSAL
VHQRKSRAFY RVQATRMMIG AGNILRKHAA EHTRRTGGPD ADKATCSHIC FESAQYQCTE
NCGSLTLGVI LDGGTGQNTF YVDYCTENGS ANAGEDYEFT EGTLFFKPGE TRKEIKVGIL
DDDIFEEDEH FFVRLQKLRL EEGGNEGTGT PPKGRLVEPL VATITILDDD HAGIFTFGQK
VLRVSESTGT LTVAVVRNSG SRGTVAVPYH TEDGSAKAGV DYEETRGEVE FTNEQTSQTL
QVRIINVEEY EKQENFFIVL EDPKWLKRGI SALLLNQGNP TPEEEEARRI SEMGKPILGE
HSRLEVIVEE SCEFKSTVDK LIKDTNLAVV VGTHSWREQF IEAVTVSAGD GDEEEGQEQR
MPNCFDYFLH ILCIFWKILF AFIPPTEYWN GWACFVVSIG VIGVLTAVIG DLASHFGCTV
GLRDSVTAVV FVALGTSVPD TFASKVAATQ DQYADASVGN VTGSNAVNVF LGIGVAWSVA
AVYWEVKGKV FRVEPGSLAF SVTLFTIFAF FSFGVLMLRR RPSIGGELGG PRIPKILTAL
LFFGLWFLYI LFSSLEAYCH IQGF
//
