ID   A0A3Q1CR81_AMPOC        Unreviewed;       928 AA.
AC   A0A3Q1CR81;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Serine/threonine-protein kinase/endoribonuclease IRE1-like {ECO:0000313|Ensembl:ENSAOCP00000021661.1};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000021661.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000021661.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q1CR81; -.
DR   STRING; 80972.ENSAOCP00000021661; -.
DR   Ensembl; ENSAOCT00000009947.1; ENSAOCP00000021661.1; ENSAOCG00000006611.1.
DR   GeneTree; ENSGT00940000165054; -.
DR   OMA; QGWNLET; -.
DR   OrthoDB; 3997280at2759; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.20.1440.180; KEN domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045133; IRE1/2-like.
DR   InterPro; IPR010513; KEN_dom.
DR   InterPro; IPR038357; KEN_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR13954:SF28; -; 1.
DR   PANTHER; PTHR13954; IRE1-RELATED; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF06479; Ribonuc_2-5A; 1.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51392; KEN; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT   DOMAIN          516..767
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          770..890
FT                   /note="KEN"
FT                   /evidence="ECO:0000259|PROSITE:PS51392"
FT   REGION          408..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          908..928
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..423
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   928 AA;  105542 MW;  F462998B2B79E661 CRC64;
     MNIIPQLQLT ITQLTETHPI IQSIIDNNLK KLKILLKDKN ANDLYAGREW GLITPLIAAV
     VNHNRDIYTY LLQKGVDPNC KSQNGWTPLH YVSITKAPLI FVEKLLEAKA NPNGWTPKQI
     FTPLQIAALC DRDDVMKVLL SAGAMVTLLP IKHPDDLIYN KKIAEMIHNF ASKGHKLCAK
     IRYFLDAEIA VPQEPPEKVF RTFNQHMLLE DPRTHLTMIE MLFTVSGKLA EKYRQRSIKW
     LKETKNVNTY ITGAVSRFSK IPKTDVKRAI DSLNAVFCTM EDIPNEQSLD IIPELLAQLC
     LKERPDIWAA VMRTLYVITQ KTKGPNDWDS SFIEKLCKTV APFVNDQYSS DIRVYTYGIF
     ANLLSVEHAA NIFTSMGINS VPEDILTSAD MEMNDKLKEG LRRLKSHFSE PNQECEDNKS
     LPESKKKKKK KKKKKERSEK TEDPNDDVCA AATDPATTVA FVESTSNGKS SHLKATNSSG
     TQPWLQLSKR WKEKLEKLVG TDISKVTRIK SLTYVNDAEF CIAKGSDGTK VFLGLRDDGT
     EVAIKKMDKD NYKALKNEEG ILRLPELDHP SIVRYVDAAE DENYGYLALQ LCEYTLEEHM
     RNNDVGLLMK KKLVSEVLES LRVLHCHNPQ ILHRDLKPQN VLIDVSGRAR LADFGISRRL
     HNDQTTVRTA SAGTTGWMAA ETLTEESVIP YKSSTDIQVA GMLIYYIFSG GHHPFGTTFV
     RVSNILYGKY SLDHVQDMVA KDLIEWMINK EPKDRPRVEE CLSHPFCWLP HKQVEYLGKI
     GNREEVANCR KADQELINSL EECAGGGSFK QWKNKFPQEL VQKMDGKNKA YPENTLGLLR
     FIRNLHEHYA KDAAQVDVTE LFPDLFGCIY KFAKTQGWNS ETPLKEMFRR EDIGAIFVFP
     ATNTEEHLSA PVQESQPCDS EFKKDERP
//