ID A0A3Q1CRA3_AMPOC Unreviewed; 443 AA.
AC A0A3Q1CRA3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=GDNF family receptor alpha-1 {ECO:0000256|PIRNR:PIRNR038071};
DE Short=GDNF receptor alpha-1 {ECO:0000256|PIRNR:PIRNR038071};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000021676.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000021676.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for GDNF. Mediates the GDNF-induced
CC autophosphorylation and activation of the RET receptor.
CC {ECO:0000256|PIRNR:PIRNR038071}.
CC -!- SUBUNIT: 2 molecules of GDNFR-alpha are thought to form a complex with
CC the disulfide-linked GDNF dimer and with 2 molecules of RET.
CC {ECO:0000256|PIRNR:PIRNR038071}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961, ECO:0000256|PIRNR:PIRNR038071}.
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DR AlphaFoldDB; A0A3Q1CRA3; -.
DR Ensembl; ENSAOCT00000009915.1; ENSAOCP00000021676.1; ENSAOCG00000006824.1.
DR GeneTree; ENSGT00940000155560; -.
DR OMA; KPECDKF; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR003503; GDNF_rcpt_A1.
DR InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR PANTHER; PTHR10269:SF3; GDNF FAMILY RECEPTOR ALPHA-1; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR PRINTS; PR01317; GDNFRALPHA1.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR038071};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038071};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR038071};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 22..104
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 143..226
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 236..330
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
SQ SEQUENCE 443 AA; 49436 MW; 5E742F8FC99375D8 CRC64;
MILATLVIGD GGSTSRHVRL DCVKASEQCL KEYSCSTKYR TMRQCVAGRE SNFSAVTGLE
AQGECRSAIE AMKQSPLYNC RCRRGMKKEK NCLRIFWSIY QSLQGNDLLE YSPYEPVNSR
LSDIFRLAPI IAAEPASTKE NNCLNAAKAC NLNDTCKKYR SAYINPCTSR VSASEVCNKR
KCHKALRQFF DKVPTKYSYG MLFCSCPAGD QTACAERRRQ TIVPVCSYED KDKTNCLSLQ
NTCKTNYICR SRLADFISNC QPEAHSISGC LRENYADCLL SYSGLIGTVM TPNYVRSFGI
SLSPWCDCSS SGNSKPDCDR FAEFFTNNRC LRNAIQAFGN GTDVGVWQPQ PPIQSTAETS
ITRRGKERNS NALDTLTDMS KLDLDGNSLY HICGTLQAQK LVSNQTVDTA LCVVSIVLFC
ALCRSVGYYK TKLLWIFEAD NDI
//
