ID A0A3Q1CT89_AMPOC Unreviewed; 1499 AA.
AC A0A3Q1CT89;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=TOG array regulator of axonemal microtubules 1 {ECO:0000313|Ensembl:ENSAOCP00000028734.1};
GN Name=TOGARAM1 {ECO:0000313|Ensembl:ENSAOCP00000028734.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000028734.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000028734.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}.
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DR STRING; 80972.ENSAOCP00000028734; -.
DR Ensembl; ENSAOCT00000031258.1; ENSAOCP00000028734.1; ENSAOCG00000018561.1.
DR GeneTree; ENSGT00940000158712; -.
DR OMA; DELCHAT; -.
DR OrthoDB; 3679265at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR GO; GO:1902903; P:regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF87; CRESCERIN-LIKE PROTEIN CHE-12; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..217
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 981..1220
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1155..1193
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1257..1489
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 315..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..882
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..939
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1499 AA; 164410 MW; B3C9E01D07A02E5A CRC64;
MIPGLITQEL HNQLLDLKNY QNRTDGVEQL KRILSDVDIR SVQSGSIEEF INFLPRLLGD
SNFKVLYGTL QVLNLLIQKL DRGVDKYFKH IVLVALKALG DTRNVTRNEY LNVFRQLMKT
VAPQQVLDLV LGNLKHKNSR VREDVLNVIM AAMLTHPRKD FNIPKLCFEV APYLVDSKRK
VRHAALELFA VFDYCLDTGK KQPLMKAVDM VELNEDAEGL MAAVQARRAR HILPKLSSDG
VVEYGLVVPK PGQRCGSGAD LDWVINGGRI SSARSHRTEP DCDRLYGYGS LGSLTDDLPL
QRRIVSAGKG KNKLPWEMSS FSSTENDQQQ CSSPNGKCSE QVAREDFLPL SRKQEAYIPS
FSSAEPPKPQ SSRRRESPVH LRRSGSLNLD PDIFKTTNFS DPDVVAPKGH VISRNPSVER
TFSLPSNSTT SFLLPSYPLA TLPGGMLTPT LPRRHADSSL SMSNTWPNKR ENGPHQRESS
PWRDTAGTAK GDLSSRRSPG PLRASLVSSS STSSFRRALS NTRTNLSISP IVPPAEQAYS
YNGQQSNAPG SPQTQQLEKN LNLDPDSISV TPDLQEDDPL DMQEMLNSLR SLRNSAAKKR
AKVSLSSPDP DSPDSAVRVD LGLDSPSHTS PVLTTSASES GLSSLSSVAN SSFNGIKTSP
GTSAASGMKP RIARVPSAKL RSSVFMDFSS LQALSQRNEL SSDVGVVGQR VMYSNGTSKT
EEEIMGPSPP LVRPAFRESV RALKPAKGSQ SHSSSRNSPG TDMPEGVIGR GMFGSAVSSS
RPGALSLEQG ELAAKPPTDP STGIQNYTLY GSHLDGDDSP RPEEVKERLK NTRFCQDKTR
LQRLDQLDSH LTQGDHAREK IRHRVRKMLS DSPTEENKPL NIKDLHLNGS TLTSTKADLH
SDESPISPTS PASPPGPQSP LKSYTPPHHP SPPTVPPNPK NLSRLRRAPS LSRTRPSLSH
SSDELSPTTV GHKKNLSEPP ELCPFSKPEL ALTQSFNLLS SEDWEKKIEG LTFLRSLAHY
HSDTLQGRLH DVCLSLIQEV KNLRSGVSRV AVCTLGDLYT HLQRAMDQEL EGTVKALLQK
AGESNAFIRQ DVDAALDCMV QHCTPTRSIN ALLTGGLSHL NAVVRKCTAQ HLANLVEKVG
AARLLSGGKD LTDRILPAVS KLAQDSSQEV RYFGRRMLLS LSSHPDFDKI LEKYIPTKDL
QTVRDTVFTL KTKGLGEMPQ DSQSARGRRS LPGSGTVRAS SLNREPLNQT NRESNSHYSC
RSQTQSIADK TEYIKQISGL LGSKDFRERI KGIDQLVTDC QHNPNMVINS IFPVFDAFKA
RLQESNSKVN LYALESLQKI IKLLKDNLSQ VVNILVPAIV DNHLNSKNNA IYSAAIGAIN
ALILNLDNIL LLQPFCTKAQ FLSGKAKVDL IEKVADLVTE LYPRKPQMVE QKVLPLLWHL
LGTSTHSGTS HGRGGSIRGA TANLCQVLHA QMGPSLSECA ASQPANVHKG LNEVLRTLS
//
