ID A0A3Q1CTB6_AMPOC Unreviewed; 803 AA.
AC A0A3Q1CTB6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Cadherin-12-like {ECO:0000313|Ensembl:ENSAOCP00000030415.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000030415.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000030415.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; A0A3Q1CTB6; -.
DR STRING; 80972.ENSAOCP00000030415; -.
DR Ensembl; ENSAOCT00000032292.1; ENSAOCP00000030415.1; ENSAOCG00000021416.1.
DR GeneTree; ENSGT00940000154673; -.
DR OMA; FTRHRPP; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF96; CADHERIN-12; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..803
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018623255"
FT TRANSMEM 611..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 85..165
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 166..274
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 275..389
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 390..494
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 494..612
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 20..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 803 AA; 88641 MW; F6212B399AAF20F8 CRC64;
MLTRNCLLLF LWGLVNEGSV SSLRPPSPPL GRSRTGREHA RSSAGPMRNG AAGFQRVKRG
WVWNQFFVLE EYMGSDPQYV GKLHTDLDRG DSAVKYTLSG EGAGSIFTID QTTGDIHALR
SLDREEKPYY TLRAQAVDID TNRPLEPESE FVIKVQDIND NEPKFLEGPY MASVPEMSPV
GTYVTQVTAT DADDPTYGNS ARVVYSILHG QPYFSVDPKT GVIKTALPNM DREVKEQYQV
LIQAKDMGGQ LGGLAGTTTV NISLSDVNDN PPRFSKSFFH LRVPESSAVG SAVGRIKAHD
LDIGKNAEVE YTIVPGDGGA MFDITTNEHN QEGILILKRP LDYETKKAYT FKVDASNAHL
DPRFQSFGAF KDTATVKINV LDVDEPPVFN KPSYVMDVYE DTPAGTIIGA VTAQDLDASS
SPVRYSIDWK SDLDSYFDID PVEGTISTNE LLDRESIAQH NISIVATKLS NPVLTSRVAV
TVHVLDINEF PPELASPYET FVCENAKVGQ VIQTFSAKDQ DLPSAGQQFS FRSPKEDLKN
KNFTIRDFGN NTAGIVTKRG GFRRRLQEIY FLPVVIDDNG YPPKSSTGTL TIRVCGCESD
GSLLTCSAEA IFLPVGLSTG ALIAILLCIV ILLVIVVLYV GLRRQKKKET LMSSKEDIRD
NVIHYDDEGG GEEDTHAFDM GTLRNPKVVK ENLYRRDIKP EMKRGPRPAI SQDSADIRDF
INQRLKEHDT DNSAPPYDSL ATYAYEGDGS VAESLSSIES LAIDLEEDYD YLSDWGPRFK
TLAGIFGEQS ETQSDSTTTE NTH
//
