ID A0A3Q1CTD5_AMPOC Unreviewed; 1013 AA.
AC A0A3Q1CTD5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Rap guanine nucleotide exchange factor 4-like {ECO:0000313|Ensembl:ENSAOCP00000028779.1};
GN Name=RAPGEF4 {ECO:0000313|Ensembl:ENSAOCP00000028779.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000028779.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000028779.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR AlphaFoldDB; A0A3Q1CTD5; -.
DR STRING; 80972.ENSAOCP00000028779; -.
DR Ensembl; ENSAOCT00000022236.1; ENSAOCP00000028779.1; ENSAOCG00000018697.1.
DR GeneTree; ENSGT00940000156075; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT DOMAIN 44..147
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 229..304
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 369..470
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 509..643
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 680..716
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 784..1011
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 1013 AA; 115921 MW; F5D4A85160A8A7B5 CRC64;
MVAAHTSSHS SESAEWIICL DKRPAERSGE DVDIILARLK NVKAFERFHP SLLQQICLCG
FYECLEKGIT LYRQGDIGTS WYAVLSGSLD VKVSETSSYQ DAVTICSLGT GTAFGESILD
NTPRHATIVT REFSELLRIE QREFRSLWEK YHHCMAGLLA PPYGVMESSA DRMPDKENIS
NNSFVSVSKH QNKNSFIESP AKPHPKCISQ VPSEKLLRAG KVLRNAILSR APHMIRDRKY
HLKTYRQCCV GTELVDWQMQ QSSCVHSRVQ AVGMWQVLLE EGVLNHVDHE LSFQDKYLFY
RFLDDEQEDA PLPSEEERKE SQEELQDTLL LLSQIGPDAH MRMILKKHPS ERTADDLEII
YEELLHIKAL SHLSTTVKRE LAGVLIFESH AKAGTVLFNQ GEEGTSWYII LKGSVNVVIY
GKGVVCTLHE GDDFGKLALV NDAPRAASIV LREDNCHFLR VDKEDFNRIL RDVEANTVRL
KEHGLDVLVL EKSLSSSRTS IQGSSASHYK YKVMSGTPEK ILEHLLEMMR LDSQFTESDS
ALDDFVLMHC VFIPNSQLCP VLLAHYHAQA SQGSEQEKLD YTLNNKRRVI RLVMRWAAVH
GDQLQQDEVS VAFLEEFFLA VSNDAKVLPT LRDQLIELER TVKRNAEDAR SLQKKHKILL
RQFSMGDEKL QKRQPIKSND EILFKVYCCD HTYTTIRVSV AASVREVIGA VADKLGSAED
LLLVNLSSAG EKSVFKPNDV SVFSTLSING RLFACRRDQL DSLTPLPEQE GPSTGSLTTF
ELMSSKDVAY HMTSYDWELF HCVHELELIY HTFGRQCVKK TTVNLDLFLR RFNEIQFWVI
TEMCLCSQLS KRVQLLKKFI KIAAHCKEYR NLNTFFAVIM GLSNPAVSRL TQTWEKLPSK
FKKFYVEFEN MMDPSRNHRA YRLTVAKLEP PIIPFMPLLI KDMTFTHEGN KTFIDNLVNF
EKMRMIANTV KIVRYCRSQT FSKFQFQSFY IDVNYTVNHF KFVQHRNTSP PAS
//
