ID A0A3Q1CTW5_AMPOC Unreviewed; 1045 AA.
AC A0A3Q1CTW5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Guanine nucleotide exchange factor DBS-like {ECO:0000313|Ensembl:ENSAOCP00000030595.1};
GN Name=MCF2L2 {ECO:0000313|Ensembl:ENSAOCP00000030595.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000030595.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000030595.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1CTW5; -.
DR Ensembl; ENSAOCT00000032404.1; ENSAOCP00000030595.1; ENSAOCG00000021687.1.
DR GeneTree; ENSGT00940000161734; -.
DR OMA; LKPMQRH; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF211; GUANINE NUCLEOTIDE EXCHANGE FACTOR MCF2L2-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT DOMAIN 76..174
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 605..784
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 796..918
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 505..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 119517 MW; A11C1A9C0E219874 CRC64;
MKRAKHVIDE IMQQEIRPLL AVDIIEQLHR QFALLSGGRG KDGAPIITFP EYSGFSEVPE
EDFLNVVTYL TSIPSLDAAS IGFIIIIDRR KDKWSSVKAS LSRIAGAFPG NLQLVLVLRP
SRFFQRAIAD LGIKLHKDDF KMKIVMLNSL SDLHGYVDKG QLTRELGGSL EYCHSQWIHH
RTAIENFAMT VKTTAQMLQK FGTDLAETEL PNDVQCTKDL LTAHTDKHNN LKDELKLALR
QGTTLFGCIK EQAAKSENHE LNPDEMENQT TVERLLAQLD ETENAFEQFW CKHHLKLEQC
LQLRHFEQDF REVKVSLDSL MESLTSLSDI GDCVARVEHL LKELKTLEEK AQPTVEKAQL
HALHGDQLIQ SNHYAVDSIR PKCVELRRVC DDFSNESKKK TDVLTKSLQI HMGIDKVNQW
CESGIYLLAS QAVDKCQSQE GAESALTDIE NFLDSAEKNQ LTELRNLHNQ YEVVLSEEIK
GSVLKALKRL EDVQEMFEKR HVSLKRLSAK QTRPIQPVAP RPESSPKRPS LKNTPRTTGN
QQPLARRASD NSNSSKQPAE VDLNKKKNIR KTKGGIKIEV MHEESQGGST HVVVTNETEE
SLSNRRRHIM TELIETERLY VEELQSIMEG YFAEMNNAEL SHLLPPSLEN KRDVLFGNLP
EIYEFHNRTF LMELENCAEK PELVGTCFLK RKEELQVYEK YCQNKPRSEV LWRQCGDSLF
FQECQKKLDH KLSLDAYLLK PVQRITKYQL MLKEMLKCSK GQGMAELEEA LATMLDIIKS
VNDSMHQIAI TGFEGNLSEL GKLLMQGSFN VWTDHKKGHS KVKDLARFKP MQRHLFLYDK
MLLFCKKREE TSDGHEKTPS YSFKHSLKMS AVGITENVKG DSKKFEVWYN GREEVYIIQA
PSMDVKNMWV SEIRKVLTGQ LEACREASQL NIYGAPMRNV RKMALKQSDS SSPESGFRRS
NPSPNMRQKR GWTQRRLLSM DTEDFETIPS SAEESSNSSE DEGNNKNGDN SRFRVQLTYE
SREAKDLSLE TGDLVQFLEE AENGN
//