ID A0A3Q1CVQ2_AMPOC Unreviewed; 1562 AA.
AC A0A3Q1CVQ2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Calmodulin-regulated spectrin-associated protein 1-B-like {ECO:0000313|Ensembl:ENSAOCP00000029634.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000029634.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000029634.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR Ensembl; ENSAOCT00000023937.1; ENSAOCP00000029634.1; ENSAOCG00000020074.1.
DR GeneTree; ENSGT00950000182975; -.
DR OMA; FIAEVFW; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF3; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT DOMAIN 228..343
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1427..1561
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1129..1180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1269..1296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..731
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1562 AA; 173490 MW; 1D52AF6D35EA38D1 CRC64;
MDVEVSAGRD STWRRAAADD DGGGGGGGGG GGGVEAQVVP LELYDSARAK IEANLRWLFA
KAYGIDDIPA DLRDPFYTDQ YEQEHIKPPI IRLLLSGELY CRVCGLILHA EQAASLQSHQ
SVIQNLSRKG IYVLEADNTP VSDLDLSSFP IKMNSHIHLI DALIMAYTVE MISIEKVVSS
VKRFSNFSAS KELPFDLEDA MVFWINKVNI KMREITEKEC KMKQHLLESP SHQKVRYRRD
HLSGRTLQHF PLLDDLFKDV CDGTALLAVI HFYCPDLIRL EDICLKEVPS IADSVYNIQL
LREFSNEYLN KCFYLNPEDL LYSPPVLKNN VMVFIAELFW WFENVKPDFV QPRDLQEVKD
VRLLLQPKSS RSYVPISNVT KRSFLTSSSS ADVLTTPLSP DLSTKQSSTS PSHSLLPLRQ
RQQKVTEESS SDVRNRSNSL TRTEGQHQGS ILAWPERRAR PLSQPAPYAL HFAQEDDADS
ISLARSISKD SLASNIMSIT PKHMLGSGLS QHRLSGQSLL SHMRIEDEEE EIEEEELVAV
IHPSAFSRKR IGSDMEQDEL EIQSAASTSR VPKTSCSPRL DTGPFTLDHQ ADSYFLEPLI
PAIPKPAKEK SISLNKQEES GESRFRPVAG ARKAAINVPS ASQRKSPMAE SNRSICTPTL
MVESVPTSLR PPTEGSAGIS QSGKKQSQGF FLHLSGESDC HSPFSTGLEA GHDSDSDIAD
LEEDDDDDDQ MELTKEVVKR GRGRFLEEGD LTEFGEGEGE SAKLREDSKV SERDDKEDGS
GRSSPCPSTI SWASSCSASG SASVKMTSFA ERKLLKLGLR DGYSSTSSSQ KTTPDGSEVA
PCPPWQLRSE PTSGWLGKEP STVLGKNMMA SPPVVPSELL QLHMQLEEQR RAIEYQKKKM
ETLSARQRLK LGKAAFLNIV KKGGGRSDTL PLPLKHPQES AELTAADRSK SKTHSCRDDS
CLDALKVQAR AGQTEGGQVN RDNKLNPMSQ DNGAEPDLNE CSRSIDLLNE AISSIQQQMM
HLSLQQDLLM KQSVVSPPDS VQSDPSTNPN TAQTELSTSD SRSYAVHFVD ISGRNPVPAR
RPPKLSSSQR SKASERKQSK EHSRAALVKL NVPSPDCILS AETGSIIESS RTDKSVQRST
TFRVRDGIGE GTRRCSDKPQ SQDPPVISNA SNSDSQDAEQ EIKAVISGKE FVGGDDSTRV
KGQLIEVDLS EVKDRLEDGS TDATDGMAEG EQKNVLGFFF KDDEKAEDEM AKRRAAFLLK
QQRKAEEARL RKQQQEAESE IKRDEARRKA EEDRIRKEEE KARRELIKQE YLRRKQQALM
EEQGLVKPRP RTKSRRNRPK SLHREESNSL SKGSTTPDLS CSHRGSTLSL ATEVDSVISG
GAESHRAGSV CSMESFPLLS RASSRNMERD WENGSIASSI TSTEYNGPKL FKEPSSKSNK
PIIINAIAHC CLAGKVNESQ KNVVLEELEK CESNHLIILF RDGGCQFRAI YSYSPDTEEI
VKFTGTGPRH ISRKMIDKLY KYSSDRKQFT VIPAKTVSVS VDALTIHNHL WQVKRPGSAR
RK
//
