ID A0A3Q1CVU1_AMPOC Unreviewed; 131 AA.
AC A0A3Q1CVU1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Islet amyloid polypeptide {ECO:0000313|Ensembl:ENSAOCP00000023036.1};
GN Name=IAPP {ECO:0000313|Ensembl:ENSAOCP00000023036.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000023036.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000023036.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium
CC and phosphate in blood by promoting the incorporation of those ions in
CC the bones. {ECO:0000256|ARBA:ARBA00003306}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the calcitonin family.
CC {ECO:0000256|ARBA:ARBA00009222}.
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DR AlphaFoldDB; A0A3Q1CVU1; -.
DR STRING; 80972.ENSAOCP00000023036; -.
DR Ensembl; ENSAOCT00000006487.1; ENSAOCP00000023036.1; ENSAOCG00000008827.1.
DR GeneTree; ENSGT00510000048671; -.
DR OMA; MYHLKVP; -.
DR OrthoDB; 3910643at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR Gene3D; 6.10.250.2190; -; 1.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR018360; Calcitonin_CS.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR InterPro; IPR000443; IAPP.
DR PANTHER; PTHR10505; CALCITONIN-RELATED; 1.
DR PANTHER; PTHR10505:SF4; ISLET AMYLOID POLYPEPTIDE; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00818; ISLETAMYLOID.
DR SMART; SM00113; CALCITONIN; 1.
DR PROSITE; PS00258; CALCITONIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR621116-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..131
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018606634"
FT DOMAIN 79..121
FT /note="Calcitonin peptide-like"
FT /evidence="ECO:0000259|SMART:SM00113"
FT DISULFID 82..87
FT /evidence="ECO:0000256|PIRSR:PIRSR621116-50"
SQ SEQUENCE 131 AA; 14538 MW; 8AC1094A52E1B727 CRC64;
MYHLRVPVLL LMLLVLLRCV TAAPSYRYFS PSSSSEQESV LPDSEGWLLP GLISNPFLGL
MGSRPRRGLT SMNSHHIEKR KCNTATCVTQ RLADFLVRSS NTIGTVYVPT NVGSATYGKR
ELLQPPSYLP L
//
