ID   A0A3Q1CW66_AMPOC        Unreviewed;       986 AA.
AC   A0A3Q1CW66;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Rho GTPase activating protein 44 {ECO:0000313|Ensembl:ENSAOCP00000029804.1};
GN   Name=ARHGAP44 {ECO:0000313|Ensembl:ENSAOCP00000029804.1};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000029804.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000029804.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q1CW66; -.
DR   STRING; 80972.ENSAOCP00000029804; -.
DR   Ensembl; ENSAOCT00000024251.1; ENSAOCP00000029804.1; ENSAOCG00000020420.1.
DR   GeneTree; ENSGT00940000157296; -.
DR   OrthoDB; 7959at2759; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR   PANTHER; PTHR14130:SF13; RHO GTPASE-ACTIVATING PROTEIN 44; 1.
DR   Pfam; PF03114; BAR; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00721; BAR; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS51021; BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT   DOMAIN          14..253
FT                   /note="BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51021"
FT   DOMAIN          259..449
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          161..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          468..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          532..935
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          965..986
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        468..482
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        532..551
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..662
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..677
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        727..742
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        774..793
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        832..862
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        863..884
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        889..907
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   986 AA;  107307 MW;  32838B9A70AC1160 CRC64;
     MKKQFNRMRQ LANQTVGRAE KTEVLSEDLL QVEKRLDLVK QVTHSTHKKL TACLQGQQGT
     DMEKRSVKSP SKKLPLTILA QCMEEGAAVL GDDSLLGKML KLCGETEEKL AQELIQFEFQ
     IERDVVEPLY VLAEVDIPNI QKQRKHLAKL VLDMDSARTR FQQSSKSSSH PSTLQPGAKS
     ESLREEMEES ANRMEICRDQ LSADMYNFVA KEIDYANYFQ TLIETQAEYH RKSLEILHSV
     LPQIKAHQEA WVEKPSFGKS LEEHLNISGR EIAFPIEACV TMLLECGMQE EGLFRVAPSA
     SKLKKLKASL DCGVLDVQEY SSDPHAIAGA LKSYLRELPE PLMTIELYDE WIQASNVQDM
     DKRLQALMAA CEKLPTDNLN NFRYLIKFLA KLSEYQDANK MTPGNMAIVL GPNLLWTHTE
     PNMTEMMTTV SLQIVGIIEP IIQHADWFFP GEIEFNLTGS YGSPIHTNHN SNYSSMPSPD
     MDQSDRKQQH DQSRRPLSVA TDNMMLEFYK KDGIRKIQSM GVRVMDTSWV SRKGSSTLAR
     KASSTPPGMQ GPGSPADTLI PEQPGELATS PSATPPPGER VCSDNVSPNR PDTSHAHPPP
     GEDRPPPPYP TSSCHTLPHH FYPKPPPCAR PVAPGPESQP PGSPPPPLRW SGFTPPAPPP
     SSSSSSSSSS LDINSNPKPS CLHFPKHSPP GDMSHAPPPD TNASPLYIKT PLVLTRHDQS
     LGNPSSLPSS APPPPPWAAC PCVRERGPPR LTSSLKSKEL SPVIGHKAIQ VAGPTVPPSS
     SPQSSSQSPH STEHSPHTLR KGSKKLAPVP PKVPYVPSGG MSDQSTGQPS PVSLSPTPPS
     TPSPYGLACP PGQVPPSSPG QTPLGTPHSL SSPPSLTGTL TKSRPAPKPR QRPSLPPPQP
     PTAPPGFTGS AMAPVPQPLE QGLLDGLSPG ESMSTDIFNY EIPSINVNLD SLIDEFSGAP
     CRRSLAVTDS QEGDAVPEEE PQSTTL
//