ID   A0A3Q1CX56_AMPOC        Unreviewed;       536 AA.
AC   A0A3Q1CX56;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Optineurin {ECO:0000256|ARBA:ARBA00018548, ECO:0000256|RuleBase:RU367122};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000030388.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000030388.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: May act by regulating membrane trafficking and cellular
CC       morphogenesis. {ECO:0000256|RuleBase:RU367122}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000256|RuleBase:RU367122}. Golgi apparatus
CC       {ECO:0000256|RuleBase:RU367122}. Golgi apparatus, trans-Golgi network
CC       {ECO:0000256|ARBA:ARBA00004601, ECO:0000256|RuleBase:RU367122}.
CC       Cytoplasmic vesicle, autophagosome {ECO:0000256|ARBA:ARBA00004419,
CC       ECO:0000256|RuleBase:RU367122}. Cytoplasmic vesicle
CC       {ECO:0000256|RuleBase:RU367122}. Recycling endosome
CC       {ECO:0000256|RuleBase:RU367122}. Endosome
CC       {ECO:0000256|ARBA:ARBA00004177}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
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DR   AlphaFoldDB; A0A3Q1CX56; -.
DR   STRING; 80972.ENSAOCP00000030388; -.
DR   Ensembl; ENSAOCT00000025350.1; ENSAOCP00000030388.1; ENSAOCG00000021349.1.
DR   GeneTree; ENSGT00530000063808; -.
DR   OMA; DMKQEMF; -.
DR   OrthoDB; 5406882at2759; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   CDD; cd09803; UBAN; 1.
DR   Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 2.
DR   Gene3D; 1.20.5.990; Nemo cc2-lz domain - 1d5 darpin complex; 1.
DR   InterPro; IPR032419; CC2-LZ_dom.
DR   InterPro; IPR021063; NEMO_N.
DR   InterPro; IPR034735; NEMO_ZF.
DR   PANTHER; PTHR31553; NF-KAPPA-B ESSENTIAL MODULATOR; 1.
DR   PANTHER; PTHR31553:SF2; OPTINEURIN; 1.
DR   Pfam; PF16516; CC2-LZ; 1.
DR   Pfam; PF11577; NEMO; 1.
DR   Pfam; PF18414; zf_C2H2_10; 1.
DR   PROSITE; PS51801; ZF_CCHC_NOA; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367122};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW   ECO:0000256|RuleBase:RU367122};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753, ECO:0000256|RuleBase:RU367122};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW   ECO:0000256|RuleBase:RU367122};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU367122};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367122};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU01142}.
FT   DOMAIN          506..536
FT                   /note="CCHC NOA-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51801"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          87..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          259..414
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          439..473
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   536 AA;  61118 MW;  ECDF79A729C15475 CRC64;
     MASGGPMMNG DISRSPNQSG TLEETLQQMN ILIQENRDLK EALRQTNLTM KERFEGLSVW
     REKQKQERDF LEGRLEEARG RMETLSLQNQ ELSKRLEESE RAGGAPGGRQ SAEMDALRAQ
     LARLQAEKND LVALNSELQL KAEQDSREDS FIEIIKVSDG GIDGLNEACG AERSRRPDLS
     MTSSRMDSEE VTVSQLLQSL RNETQRGERL QAELQACAAR IRELEERKLS TEESTQTAEP
     ETTEAKEDPR KEDKAASEVE NLKSQMMTLF KELQQAQSKL DEAEGMKKNL QDRCREVEQD
     VVTLKAQLVE KQAVQSENDR LKLQLGSMQA QSLMEQRKAG EERNNLAQLK DAYTKLFEDY
     TELKDERKKR QAQLVEKDVV DELQQRLTAA EEALAVKQNK IDDMKQEMFQ KEKELETISV
     FQAQAEVYSS DFYAERAARE KLHEEKERLA AQLEYIKKQN SQLQEEMDSL GRRSLNEMQR
     RHVPPAGNPH GAGASLVGRG TDWQHQGNIP EHACPKCNEI LPDLDSLQIH IMDCIN
//