ID   A0A3Q1CXX0_AMPOC        Unreviewed;       297 AA.
AC   A0A3Q1CXX0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Regucalcin {ECO:0000256|ARBA:ARBA00016808};
DE            EC=3.1.1.17 {ECO:0000256|ARBA:ARBA00013227};
DE   AltName: Full=Gluconolactonase {ECO:0000256|ARBA:ARBA00032464};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000023646.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000023646.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucono-1,5-lactone + H2O = D-gluconate + H(+);
CC         Xref=Rhea:RHEA:10440, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16217, ChEBI:CHEBI:18391; EC=3.1.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00001589};
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the SMP-30/CGR1 family.
CC       {ECO:0000256|ARBA:ARBA00008853}.
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DR   AlphaFoldDB; A0A3Q1CXX0; -.
DR   STRING; 80972.ENSAOCP00000023646; -.
DR   Ensembl; ENSAOCT00000004843.1; ENSAOCP00000023646.1; ENSAOCG00000009916.1.
DR   GeneTree; ENSGT00390000014995; -.
DR   OMA; WAGTMRY; -.
DR   OrthoDB; 3091635at2759; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0030234; F:enzyme regulator activity; IEA:InterPro.
DR   GO; GO:0004341; F:gluconolactonase activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR008367; Regucalcin.
DR   InterPro; IPR013658; SGL.
DR   InterPro; IPR005511; SMP-30.
DR   PANTHER; PTHR10907; REGUCALCIN; 1.
DR   PANTHER; PTHR10907:SF47; REGUCALCIN; 1.
DR   Pfam; PF08450; SGL; 1.
DR   PRINTS; PR01791; REGUCALCIN.
DR   PRINTS; PR01790; SMP30FAMILY.
DR   SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT   DOMAIN          16..261
FT                   /note="SMP-30/Gluconolactonase/LRE-like region"
FT                   /evidence="ECO:0000259|Pfam:PF08450"
SQ   SEQUENCE   297 AA;  32196 MW;  11F4C9BE763D7879 CRC64;
     MSSVKVESVV EVSALVGEGP VWEEPEQTLL FVDIPGHKIH RWNPATNQIQ SVETADPVGF
     AVPRRSGGYV AGVGRSIVAV DWSTQVMTSL ARVDEDKLNT RLNDGKVDPI GRLWAGTMVA
     EGQQDDRKQG SLFSVTSDLT VTKHLSQVDI SNGMDWSLDQ KTFFYIDSLS LTVDAFDYDV
     TTGKIGNRRV VYRMQEGEGL PDGMTMDAGG RLWVACYNGG RVINIDPATG VRLQTIPLPA
     TKTTSCCFGG PDYSDLYVTS ASLGLDQSEL KHQPQAGHTF RVTGLGVKGR PSHSFSG
//