ID   A0A3Q1CYZ8_AMPOC        Unreviewed;       815 AA.
AC   A0A3Q1CYZ8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Discs large MAGUK scaffold protein 3 {ECO:0000313|Ensembl:ENSAOCP00000030889.1};
GN   Name=DLG3 {ECO:0000313|Ensembl:ENSAOCP00000030889.1};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000030889.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000030889.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q1CYZ8; -.
DR   Ensembl; ENSAOCT00000032568.1; ENSAOCP00000030889.1; ENSAOCG00000022236.1.
DR   GeneTree; ENSGT00940000159565; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   CDD; cd12029; SH3_DLG3; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR035763; DLG3_SH3.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF28; DISKS LARGE HOMOLOG 3; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          134..221
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          229..316
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          384..465
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          499..569
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          625..800
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          41..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   815 AA;  89770 MW;  A0F2C1F8086AFB81 CRC64;
     MHKHHHCCKC PECYEVTRMA ALRRMDAPSY GGDWQAEPYG YPPGYGGGQT LPPPASGGGG
     SMGGGGGTLG RSKGKIMSGG GPGGPNPKGQ SKGGPKVNGN NSSGQGGWWP ECTCTNREWY
     DQVNGSDGMY KYEEIILERG NSGLGFSIAG GIDNPHIPDD PGIFITKIIP GGAAAMDGRL
     GVNDCVLRVN DVDVSEVVHS RAVEALKEAG PVVRLLVRRR QAPPETILEV NLLKGPKGLG
     FSIAGGIGNQ HIPGDNSIYI TKIIEGGAAQ KDGRLQTGDR LLAVNNIVLQ DVRHEEAVAA
     LKNTSDMVYL KVAKPGPVHL NDMYAPPDYS STFPTMVDNH VSHNYMGAME PKPVYPPPQV
     TPSRYSPVPR HMLGEEDFTR EPRKVLLHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL
     SGELRRGDRI LSVNGVNLRN ATHEQAAAAL KRAGQTVTII AQYRPEEYSR FESKIHDLRE
     QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS QGLSFSYGDI LHVINASDDE
     WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA RTGMIESNRD FPGLSDDFYG
     SKSLKGQEDT ILSYEPVIRQ EIHYTRPVII LGPMKDRVND DLISEFPHKF GSCVPHTTRP
     RRENEMDGQD YHFVASREQM EKDIQDNKFI EAGQFNENLY GTSILSVRTV AERGKHCILD
     VSGNAIKRLQ QAQLYPIAIF IKPKSIEALM EMNKRQTYEQ ANKVFDKAVK LEQDFGEYFT
     AIVQGDSLEE IYNKIKLIIE EQSGPYIWIP SSEKL
//