ID   A0A3Q1D208_AMPOC        Unreviewed;       886 AA.
AC   A0A3Q1D208;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Sorting nexin 13 {ECO:0000313|Ensembl:ENSAOCP00000032059.1};
GN   Name=SNX13 {ECO:0000313|Ensembl:ENSAOCP00000032059.1};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000032059.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000032059.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   AlphaFoldDB; A0A3Q1D208; -.
DR   STRING; 80972.ENSAOCP00000032059; -.
DR   Ensembl; ENSAOCT00000028619.1; ENSAOCP00000032059.1; ENSAOCG00000024141.1.
DR   GeneTree; ENSGT00950000182856; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IEA:Ensembl.
DR   GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   CDD; cd06873; PX_SNX13; 1.
DR   CDD; cd08719; RGS_SNX13; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037437; SNX13_PX.
DR   InterPro; IPR037896; SNX13_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        30..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          97..284
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          373..514
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          560..682
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   886 AA;  102399 MW;  60E33F46EF97FA55 CRC64;
     MFAEASLSIW GWGGLGVVLF LVTFGPFAIF YLAFYIFCFI GGGFAVTLLY GKINSEKHLE
     KCEQSYLPPT QIGILKTLDE MKLEIRPIKI DRRLTGSSFI DEPLQQVIQF ALRDYIQYWY
     YTLSEDESFL LEIRQTLQNA LVQFSTRSKE VDWQPYFTTR LVDDFATHLR VFRKAQDRLA
     DREDKQRDIT EELVDSFFEA EVEMERKICR DVVCTSHKDE EGFLRDLCEL LLYLLLPPGD
     FHNKNMRYFL REVLARGVLL PLINQLSDPD YINQFVIWMI RDSSCNYEAF MNILKLTDKP
     AELEAVKDKV LEELQYLRSL DTAGDDINVI KNQINSLLFV KKVCETRIQR LQSGKEVDAL
     KLAANFGKLC VIPLDHILIH NIALQFFMDF MQAAGAQAEL FFWLTVEGYR VTAQQQLEAM
     QGWQKDGGKK QPSATKGLLK AAALGVYEQY LSEKASPRVQ VDEESVTKLG EKLQKDDPTP
     EIFDEIQRKV YDMMLRDERF YPSFKQSPLY VRMLAELDML KEPSYRGSDD GDGESFNGSP
     TGSINLSLDD LSNSCHDETM QLHAFISDTG VCNDHGKTYA LYAITVFRRN QDGSEDCWKT
     YRRYSDFHDF HMRITEQFEN LASILKLPGK KTFNNMDRDF LEKRKKDLNA YLQLLLNPEM
     VKACPTLIPY VYDFLENKAY SKGKGEFARK IDTFVNPLRS SMRNMSNAVK ALPDSLAEGM
     TKVSDNMGRM SERLGQDIKQ SIFKVPPLLP KSDIDPDHCR VSAQLDDNVD DNIPLRVMLL
     LMDEVFDLKE KNQWLRRNIK NLLQQLIRAT YGDTINRKIV DHVDYLTSPE QVADYVKKFR
     DSYWPNGILA ETPPRRDKSI RMRTRVAAKT SLLGIMPGEN PDFTYL
//