ID A0A3Q1D212_AMPOC Unreviewed; 1062 AA.
AC A0A3Q1D212;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Disabled homolog 2-interacting protein-like {ECO:0000313|Ensembl:ENSAOCP00000032064.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000032064.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000032064.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1D212; -.
DR STRING; 80972.ENSAOCP00000032064; -.
DR Ensembl; ENSAOCT00000028625.1; ENSAOCP00000032064.1; ENSAOCG00000024138.1.
DR GeneTree; ENSGT00940000155853; -.
DR OMA; HMTATSP; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 2.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT DOMAIN 1..76
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 67..185
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 245..437
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 540..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 907..973
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 552..571
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..812
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1062 AA; 117478 MW; AE645FE3D25C0E55 CRC64;
MRRLRCGSQE SLLSAGCVSS LELRMDQSVI IKPVHSSLLG QDYCFEVTTS TGTKCFSCRS
AAERDKWMEN LRRAVHPNKD NSRRLENVLT VWVVEAKDLP AKKRYFCELC LDDSLYARTS
CKLRMDNVFW GERFDFSSLP SVSSVTLHLY KDTDRKRKKD KSSYVGLVNI PVATVTGRQL
VEKWYSVSTP STSRGKSSVP TVRVKARYQS IVILPMEQYK EFAEYISSNY LLLCSTLEAS
ISLRAKEELA AALVHILHST GKAKDFLTDL MMSEVDRCRD NDQLIFRENT LATKSIEEYL
KLIGQKYLQD ALGEFIKALY ESDENCEVDP SRCSTSDLPE HQANLRMCCE LAFCKILDSY
RVFPRELKEV FASWRQECGN RGRPDISERL ISASLFLRFL CPAVMSPSLF DLMQEYPDER
TARTLTLIAK VIQNLANFSK FGTKEEYMLF MNDFVERQWS SMQRFLQEIS NPDGLNHTAG
FDGYIDLGRE LSSLHTLLTE LDQSCLVKLS PLPRILRDVS SALCNPGGVS TVAGVSTMGG
VSVSSPEQQR VMSPPPLSPP PLSPPLSPPL AACNPSIGLQ GSMGLDGGLV DFTRLPSPTP
ENKDLFFVTK GSSLQPASGL QGSPAPSSSY SEPNENEAAF EMTNGGRREG PELTNESRSL
SLVDLQDSSP SDGLDDGQWQ RRTGLLPLSF QNPVYHMTAT SPRQPQQQAD AMLSDGSAGS
QGNADDRNTV ATKPAFLTQM SVGLGGGERG DRMSAMSSSS SGEEYSRRAL SLTDTLTGSS
PLPRQNSSGP QRRIDQPPPP SSAPPGPPRG RTPPSMLSGG SGGGPAYPPR PASGSMMSSS
PDWPSSGQSR LRQTSSSSKG DSPEKQRPAA KAPSPCALDR TAAWLLNMNS ASSYGETEDD
RHDDALVEKY QQEIAVLQEK LRVAALRQEE CEARLMVQDQ QNQRMLQEYQ ARLEDTESRL
RRLQDDKDLQ MNSIISRLMA VEEELKKDHS DMQAVVDSKQ KIIEAQEKRI SSLDAANTRL
MTALTQLKER YAVTSQRNGL SPSNTSSLQI TENGEFRNSG NC
//
