ID A0A3Q1D394_AMPOC Unreviewed; 1165 AA.
AC A0A3Q1D394;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000025476.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000025476.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q1D394; -.
DR STRING; 80972.ENSAOCP00000025476; -.
DR Ensembl; ENSAOCT00000000105.1; ENSAOCP00000025476.1; ENSAOCG00000013304.1.
DR GeneTree; ENSGT00940000156107; -.
DR OMA; THEEVCP; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:UniProtKB-UniRule.
DR CDD; cd00064; FU; 3.
DR CDD; cd12095; TM_ErbB3; 1.
DR Gene3D; 6.10.250.2930; -; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR044912; Egfr_JX_dom.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF88; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 3.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR000619};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000619}.
FT TRANSMEM 589..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 659..916
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 988..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 665..673
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 692
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1165 AA; 130164 MW; 5FD64F89E5B845B3 CRC64;
ISPRPGLLQV CHGTQNGLSS TGSQENQYNL IKDRYDGCEI IMGNLEITQI ESNWDFSFLK
TIREVTGYVL IAMNHFQELP LRQLRVIRGN SLYERRFALS VFFNYPKDGS NGLRQLGLTN
LTDCLFLTSA DCISVSSSLS GPCHKSCGDY CWGPNEDQLT KTVCAPQCNG RCFGTSPRHC
CHIECAAGCT GPLDVDCFAC RHFNDSGACV PQCPQTLIYN KQTFQMETNP NAKYQYGSIC
VSQCPTHFVV DGSSCVSVCP LDKMEVEREG QRQCELCSGL CPKVCEGTGA EHRQTVDSSN
IDSFINCTKI QGSLHFLVTG ILGDDFKNIP PLDAKKLEVF HTVREITDIL NIQSWPKELN
DLSVFSSLTT IQGRSLYKRY SLMVMHIPTL TSLGLRSLRE ISDGSVYISQ NANLCYHHTV
NWTQLFRGRR VGVNNLNNNR QLAECVAEGH VCDPLCSDSG CWGPGPDQCL SCRNYSRDGT
CVGSCNFYTG VTREFASRKG ECVICHPECK PQRGKASCTG PGADECVACA NLRDGPYCMS
SCPTGVNDGQ KGLIFKYPNR EGHCEPCHHN CTQGCSGPGL HDCLQTARMA ITGIALGVPA
GLIFCLVLFF LGVLYHRGLA IRRKRAMRRY LESGESFEPL GPGEKGTKVH ARILRPSELK
KIKALGLGVF GTVHKGFWTP ERETVKIPVA IKTIQDSSGR QTFTEITDHM LSMGSLDHPY
IVRLLGICPG ASLQLVTQLS SQGSLLEHIR QHKNSLDPQR LLNWCVQIAK GMYYLEEHCM
VHRNLAARNI LLKNDYQVQI SDYGVADLLY PDDKKYVYTD TKTPIKWMAL ESILFRRYSH
QSDVWSYGVT VWEMMSFGAE PYASVQPQEV PSLLEKGERL SQPHICTIDV YMVMVKCWMI
DENIRPTFKE LASDFTRMAR DPPRYLVIKV GSSNYFTSRI SQSTRRNSRL KNNLRLVVMN
PSQEYEIMNT ECDALPCSAS SVSSHGDDPT AALCQNISPL PSPTEEKTHK ETLTPTSAVR
SKQVQQACGG NVAEQKDSTE KPNRDFTNEI KSVDDQPEAS QGFGRYEYMD IRRSDVLTAR
GEMLEEYEEM TRFRVVPGRW EHTEYQNLPA KGRDVSEEMG GGRCAGIGEY IKVCADMGEP
GSNTSFDNPD YWHSRLFLKP DAVRT
//
