ID   A0A3Q1D7J6_AMPOC        Unreviewed;      1276 AA.
AC   A0A3Q1D7J6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000026936.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000026936.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00011010}.
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DR   AlphaFoldDB; A0A3Q1D7J6; -.
DR   STRING; 80972.ENSAOCP00000026936; -.
DR   Ensembl; ENSAOCT00000018538.1; ENSAOCP00000026936.1; ENSAOCG00000002541.1.
DR   GeneTree; ENSGT00940000155378; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1170.10; -; 1.
DR   Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR   InterPro; IPR036859; CAP-Gly_dom_sf.
DR   InterPro; IPR000938; CAP-Gly_domain.
DR   InterPro; IPR022157; Dynactin.
DR   PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR   PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR   Pfam; PF01302; CAP_GLY; 1.
DR   Pfam; PF12455; Dynactin; 1.
DR   SMART; SM01052; CAP_GLY; 1.
DR   SUPFAM; SSF74924; Cap-Gly domain; 1.
DR   PROSITE; PS00845; CAP_GLY_1; 1.
DR   PROSITE; PS50245; CAP_GLY_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT   DOMAIN          34..76
FT                   /note="CAP-Gly"
FT                   /evidence="ECO:0000259|PROSITE:PS50245"
FT   REGION          84..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          173..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          997..1049
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1093..1120
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        84..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1276 AA;  141196 MW;  89D624164342C526 CRC64;
     MSSSGTVESG KPPKIGSIVE VTGKGQRGTV AYIGTTLFAS GKWVGVILDE PKGKNDGTVQ
     GKRYFTCEEN HGIFVRQSQI QVVEEGSGAT SPDTPESGTT KIPKQKDIPE TPRTTKQIPV
     NVKNVKSSTR RSGKWGTPRL TETTSLPSLL VRFPKGSSVS LTASRESLST SLSGDVSEAG
     LSSQQGALGA PVVPQPSGSP AAAATAVPAT PSKGEPAISK QEEESLRAQV KDLEEKLETL
     KMKRTEDKAK LKELEKHKIQ LEQLQEWKTK MQEQQTDLQK QLKEAKKDAR EAQEAKDRYM
     EEMSDTADAI EMATLDKEMA EERAESLQVE VDTLKEKVEE LSMDLEILRH EISEKGSDGA
     ASSYQVKQLE EQNSRLKEAL VRMRDLSASE KQEHVKLQKQ MEKKNTELET LRTQKEKLQE
     EVKQAEATID ELKEQVDAAL GSEEMVETLT ERNLDLEEKV RELRETVTDL EAINEMNDEL
     QENARETEME LREQLDMSAA KVREADKRVE AAQETVADYQ QTISKYRELT ASLQDANREL
     ISQQNANAEQ VQQPPAELFD FKIKFAETKA YAKAIEMELR KMEVAQSNRQ VSLLTSFMPD
     SFLRHGGDHD CVLVLLLIPR LICKAELISK QAQEKFDLNG NLVQGAGLRG PPGEQRSFAS
     GLVYSLSLLQ ATLHKYEQAL NTCSVEVFKR MGTLYTEMSF HERSLDYFID LLHKDQLDET
     VQVEPLTKAI KYYQQLYSVH LAEHTEDCTV QLADHIKFTQ SALDCMGVEV ARLRAFLAAG
     QDGSGLSVLL KDLDTSCSDI RQFCKKIRRR MPGTDVAGVP AALNFGPPVS ETLTECRRQL
     TRVVAVLQEV TAAGAQMVAP LGEQEGLNAL RLEDTACKVV EQIYGTHGVN GPELLRQSCS
     SVIATMNKMA TAMQEGEYDA DKPQGKTSPV EVRASTVRAE MTDAEGLGVK LEDRETVIKE
     LKKSLKIKGE ELSEASVRLS LLEKKLDTST KDADERVEKI QTKLDENLAL LKKKEKEFEE
     TMDALQADID QLEAEKAELK QRINNQSKMT IEGLRSSPAS GIASIVQGSA GGVPPSMAGP
     MQVVDSPLLR QQVEAQRLSI KHLKNENNRL KAEKMRAQLA SLPPLCPPRL PQVSKESSMP
     PEGLNTGIYR RTDQLLATLL KLSAEVKVVD ITGKTAVSAS AQLLEQTARL QNLSDALDKL
     KGEVAEHVVS YQPGAKASSD FATFPISSFV KAKEEKQGGT VFVGRVAIPC TRGQEQVHRL
     VLSQQQLHKV HRLLMV
//