ID A0A3Q1DBU8_AMPOC Unreviewed; 680 AA.
AC A0A3Q1DBU8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Solute carrier family 25 member 12 {ECO:0000313|Ensembl:ENSAOCP00000028581.1};
GN Name=SLC25A12 {ECO:0000313|Ensembl:ENSAOCP00000028581.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000028581.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000028581.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) = 3-
CC sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out);
CC Xref=Rhea:RHEA:70967, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:61085; Evidence={ECO:0000256|ARBA:ARBA00036383};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-
CC alanine(in) + L-aspartate(out); Xref=Rhea:RHEA:70975,
CC ChEBI:CHEBI:29991, ChEBI:CHEBI:61085;
CC Evidence={ECO:0000256|ARBA:ARBA00037019};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + L-aspartate(in) + L-glutamate(out) = H(+)(in) + L-
CC aspartate(out) + L-glutamate(in); Xref=Rhea:RHEA:70783,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991;
CC Evidence={ECO:0000256|ARBA:ARBA00036177};
CC -!- SUBUNIT: Homodimer (via N-terminus). {ECO:0000256|ARBA:ARBA00038674}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
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DR AlphaFoldDB; A0A3Q1DBU8; -.
DR STRING; 80972.ENSAOCP00000028581; -.
DR Ensembl; ENSAOCT00000021869.1; ENSAOCP00000028581.1; ENSAOCG00000018336.1.
DR GeneTree; ENSGT00940000155963; -.
DR OMA; QRQHAHE; -.
DR OrthoDB; 1220009at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0043490; P:malate-aspartate shuttle; IEA:UniProt.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45678:SF7; CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1; 1.
DR PANTHER; PTHR45678; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 86..121
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 157..192
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 324..416
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 424..508
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 516..604
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REGION 660..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 75228 MW; E5518035704F5C45 CRC64;
MAVKVQATKR GDPHDLKAIF LKYASVVEDG EHYMTPRDFV QSYLGLHTQP QHNPKTVELI
AGVADTTKDG LISFQEFLAF ESVLCAPDAM FIVAFQLFDK TGTGNISFEN VRDIFSQTTV
HHHIPFNWDC EFIRLHFGHE RNKNLSYTEF TQFLQELQFE HARQAFAQKD KNKSGTITAL
DFSDIMATIR HHMLTPFVEE NLVSAAGGST SHMVSFSYFN AFNALLNNME LVRKIYSTLA
GTHRDTLVTK EEFVHAANKF GQITPMEIDI LYQLVGLHSH SGRLNHADIE RIAPLEEGAM
PYHLAEAHRQ HAHETSRSVW LQAAESAYRF TLGSIAGATG ATAVYPIDLV KTRMQNQRST
GSFVGELMYK NSFDCAKKVL RYEGFFGFYR GLLPQLIGVA PEKAIKLTMN DFVRDKFTRQ
DDTIPLPAEI LAGGCAGASQ VIFTNPLEIV KIRLQVAGEI TTGPRVSALN VVRDLGFFGL
YKGAKACFLR DIPFSAIYFP VYAHTKESLA DEDGQLGAVQ LLTAGAIAGV PAASLVTPAD
VIKTRLQVAA RAGQTTYNGV IDCFRKILKE EGFRAFWKGA GARVFRSSPQ FGVTLVTYEL
LQRWFYVDFG GHRPAGSEPT PKPAIEDLPS VTADHVGGYR LAAATFAGVE RKFGLHLPKF
KPSGEATIKP AASKTEPQAS
//
