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Database: UniProt
Entry: A0A3Q1DDT7_AMPOC
LinkDB: A0A3Q1DDT7_AMPOC
Original site: A0A3Q1DDT7_AMPOC 
ID   A0A3Q1DDT7_AMPOC        Unreviewed;       626 AA.
AC   A0A3Q1DDT7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000029481.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000029481.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4-
CC         aminobutanoate(in) + chloride(in) + 2 Na(+)(in);
CC         Xref=Rhea:RHEA:70687, ChEBI:CHEBI:17996, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:59888; Evidence={ECO:0000256|ARBA:ARBA00033998};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70688;
CC         Evidence={ECO:0000256|ARBA:ARBA00033998};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-
CC         alanine(in) + chloride(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71247,
CC         ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57966;
CC         Evidence={ECO:0000256|ARBA:ARBA00034027};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71248;
CC         Evidence={ECO:0000256|ARBA:ARBA00034027};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chloride(out) + 2 Na(+)(out) + taurine(out) = chloride(in) + 2
CC         Na(+)(in) + taurine(in); Xref=Rhea:RHEA:71223, ChEBI:CHEBI:17996,
CC         ChEBI:CHEBI:29101, ChEBI:CHEBI:507393;
CC         Evidence={ECO:0000256|ARBA:ARBA00034047};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71224;
CC         Evidence={ECO:0000256|ARBA:ARBA00034047};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chloride(out) + hypotaurine(out) + 2 Na(+)(out) = chloride(in)
CC         + hypotaurine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:71243,
CC         ChEBI:CHEBI:17996, ChEBI:CHEBI:29101, ChEBI:CHEBI:57853;
CC         Evidence={ECO:0000256|ARBA:ARBA00034007};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71244;
CC         Evidence={ECO:0000256|ARBA:ARBA00034007};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC       2.A.22) family. SLC6A6 subfamily. {ECO:0000256|ARBA:ARBA00006123}.
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DR   AlphaFoldDB; A0A3Q1DDT7; -.
DR   Ensembl; ENSAOCT00000023610.1; ENSAOCP00000029481.1; ENSAOCG00000001890.1.
DR   GeneTree; ENSGT00940000154583; -.
DR   OMA; TTEYSQP; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005369; F:taurine:sodium symporter activity; IEA:InterPro.
DR   GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR   CDD; cd11510; SLC6sbd_TauT; 1.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR002434; Na/ntran_symport_taurine.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616:SF141; SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRANSPORTER; 1.
DR   PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR   Pfam; PF00209; SNF; 1.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   PRINTS; PR01200; TAUTRANSPORT.
DR   SUPFAM; SSF161070; SNF-like; 1.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Neurotransmitter transport {ECO:0000256|ARBA:ARBA00022775};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   Symport {ECO:0000256|RuleBase:RU003732};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003732};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT   TRANSMEM        50..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        80..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        218..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        245..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        290..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        327..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        381..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        430..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        460..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        506..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        545..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   626 AA;  70081 MW;  72694C1FEA1F3DB7 CRC64;
     MAQKEKLQCL KDFHKDTLKP SPGKSPGTRP EDEAEGKHPQ REKWASKLDF VLSVAGGFVG
     LGNVWRFPYL CYKNGGGAFL IPYFIFLFGG GLPVFFLEVA LGQFTSEGGI TCWEKLCPIF
     TGIGYASIVI VSLLNIYYIV ILAWGLYYLF QCFQPELPWA KCKQPWNTDR CIEDTYRKNK
     TLWVAANASN FTSPVTEFWE HNVLGITSGI EDIGPVKWDL ALCLLLVWVI CFFCIWKGVK
     STGKVVYITA TFPFVMLIVL LIRGVTLPGA SEGIKFYLYP DLARLKDPEV WIDAGTQIFF
     SYAICLGAMT SLGSYNKYKY NCYRDCLLLG ALNSGTSFVS GFAIFSVLGF MAQEQGVDIA
     DVAESGPGLA FIAYPKAVTM MPFPTLWAIL FFIMLLLLGL DSQFVEVEGQ ITSLVDLYPS
     FLRKGYRREV FIAIICCISY LLGLTMVTKG GMYVFQLFDY YAASGVCLLW VAFFECIAVA
     WVYGVDNFYD AVEDMIGYRP NPWMKWSWSV ITPLLCMGCF IFSLVRYKPL TYNKVYKYPD
     WAVGIGWTLA LASMICIPMV VVIKIIRSDG PLIERIKAVA APVRGGASSR PADHRGPKDL
     TYPLDPNGNK GLLMKAPTHT IVETMM
//
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