ID A0A3Q1EBB0_9TELE Unreviewed; 492 AA.
AC A0A3Q1EBB0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Calcium uptake protein 1, mitochondrial {ECO:0000256|ARBA:ARBA00040181};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000000693.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000000693.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane
CC space {ECO:0000256|ARBA:ARBA00004569}.
CC -!- SIMILARITY: Belongs to the MICU1 family. MICU1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038333}.
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DR AlphaFoldDB; A0A3Q1EBB0; -.
DR STRING; 80966.ENSAPOP00000000693; -.
DR Ensembl; ENSAPOT00000016434.1; ENSAPOP00000000693.1; ENSAPOG00000001914.1.
DR GeneTree; ENSGT00950000183079; -.
DR InParanoid; A0A3Q1EBB0; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; IEA:InterPro.
DR CDD; cd16173; EFh_MICU1; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039800; MICU1/2/3.
DR PANTHER; PTHR12294:SF1; CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12294; EF HAND DOMAIN FAMILY A1,A2-RELATED; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00022792};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 233..268
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 424..459
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 65..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 55570 MW; 7B5CFD0313DC8312 CRC64;
MMFRLRALSA VSVGLAQLSR RYHNGAVRGS GRRRLMLAAL AGATGVSASA GLLWQRAYAD
AGSSVRHAEQ PGGDEAEFVR DADSETESEK SVEPSSGDEE AKDEGGDGKK KKPRSGFRDR
KVMEYENRIR AYSTPDKIFR YFATLKVISE HGDAEVYMTP QDFIRSITPN EKQPENLGLD
QFIVKRYDGK DFWQKIAQER EKFADEDSIF YSLGECGLIS FSDYIFLTTV LSTPQRNFEI
AFKMFDLNGD GEVDLEEFEQ VQSIIRSQTS MGMRHRDRST TGNTLKTAGC SSALTTYFFG
EDLKGKLTIG SFLEFQRKLQ HDVLKLEFER NDPVDGRISE RQFGGMLLAY SGVQSRKLKQ
MQKGLKKMFK DAQGITFQEV ENFFTFLKNV NDVDTALSFY HMAGASIDKV TMKQVARTVA
KVELSDHVCD VVFALFDCDG NGELSNKEFI AIMKQRLMRG LEKPKDMGFT RLVRAMWKCA
QDTAWDFATP KT
//
