ID   A0A3Q1EDC2_9TELE        Unreviewed;       246 AA.
AC   A0A3Q1EDC2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Neurturin-like {ECO:0000313|Ensembl:ENSAPOP00000002191.1};
GN   Name=NRTN {ECO:0000313|Ensembl:ENSAPOP00000002191.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000002191.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000002191.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC       {ECO:0000256|ARBA:ARBA00009832}.
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DR   AlphaFoldDB; A0A3Q1EDC2; -.
DR   STRING; 80966.ENSAPOP00000002191; -.
DR   Ensembl; ENSAPOT00000013867.1; ENSAPOP00000002191.1; ENSAPOG00000003558.1.
DR   GeneTree; ENSGT00950000182993; -.
DR   InParanoid; A0A3Q1EDC2; -.
DR   OrthoDB; 4316464at2759; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd19383; TGF_beta_Neurturin; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR043401; GDNF_fam.
DR   InterPro; IPR001839; TGF-b_C.
DR   PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR   PANTHER; PTHR12173:SF3; NEURTURIN; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT   DOMAIN          139..246
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          36..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..77
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   246 AA;  27401 MW;  385976332E6293EB CRC64;
     MKLWKGATFA FMLCGAALST ILVRNMATGG QFKLKTEYPH TSSSSSRPSS SLESTSRTSS
     SSSSSSSSSS SLAGPRVSPQ QMGGLHRRIR SADDMNVVLS EFSMMFQSFT EGELQHVIGT
     LLDRKKGKSR RLAENQARRT KRARRQKPCT LRELELTVSE LGLGYESDET VLLRYCSGKC
     TAHRHNYDIT MQHMMQTGFK KKGRKDKVIN GPCCRPTAFE KDFSFLDNNS RYHTIQNVSA
     KNCGCV
//