ID A0A3Q1EHG1_9TELE Unreviewed; 746 AA.
AC A0A3Q1EHG1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000002517.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000002517.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR AlphaFoldDB; A0A3Q1EHG1; -.
DR Ensembl; ENSAPOT00000013318.1; ENSAPOP00000002517.1; ENSAPOG00000000851.1.
DR GeneTree; ENSGT01080000257420; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16855; STAT5_CCD; 1.
DR CDD; cd16849; STAT5_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR046994; STAT5_CCD.
DR InterPro; IPR035858; STAT5a/5b_DBD.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF39; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 589..690
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 134..168
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 746 AA; 85320 MW; 1DC08112D01BB858 CRC64;
MAVWIQAQQL QGDALHQMQS LYGQHFPIEV RHYLSQWIEG QLWDAIDLEN PQEEFKAKRL
LDSLIQELQN KAEHQVGEDG FLLKIKLGHY ASQLKSTYDR CPLELVRCIK HILYTEQRLV
REATNSSSPV GGMMDSMSQK YQQINQAFEE LRLLTQDTEN DLRKLQHNQE YFIIQYQESL
RIQAQLTSLA TLPPADRQLR EPALLSKRAT VEAWLTREAN TLQKYRLDLA EKHQKTLQLL
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG GLDILQSWCE KLAETIWQNR QQIRRAEHLR
QQLPIPGPIE ELLNELNSTI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL
NVHMNPPQVK ATIISEQQAK ALLKNENTRN DSSGEILNNN CVMEYHQTTG TLSAHFRNMS
LKRIKRSDRR GAESVTEEKF TILFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDNNATA
TVLWDNAFAE PGRVPFLVPD KVLWPQLCDA INMKYKAEVQ SNRGLSEENL VFLAQKAFSS
SSNNPDDYRS MTMTWSQFNR ESLPGRNFTF WQWFDGVMEL TKKHLKPHWN DGAILGFVNK
QQAQDMLMSK PNGTFLLRFS DSEIGGITIA WVAENPNKAG ERMVWNLMPY TTKDFSIRSL
ADRISDLNHL LFLYPDRPKD EVFSKYYTPP LSKAVDGYVK PQIKQVVPEF ATANPDPASG
NPTYMDQGAS PAPVNHPHTY GIYPPM
//
