ID A0A3Q1EIA5_9TELE Unreviewed; 1128 AA.
AC A0A3Q1EIA5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Zinc finger protein 516 {ECO:0000313|Ensembl:ENSAPOP00000003503.1};
GN Name=ZNF516 {ECO:0000313|Ensembl:ENSAPOP00000003503.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000003503.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000003503.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A3Q1EIA5; -.
DR STRING; 80966.ENSAPOP00000003503; -.
DR Ensembl; ENSAPOT00000011637.1; ENSAPOP00000003503.1; ENSAPOG00000005020.1.
DR GeneTree; ENSGT00940000160839; -.
DR InParanoid; A0A3Q1EIA5; -.
DR OrthoDB; 3849084at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45925; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR45925:SF3; ZINC FINGER PROTEIN 516; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF13909; zf-H2C2_5; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 43..70
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 71..93
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 223..247
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 251..278
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 311..338
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 503..530
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1042..1069
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1128 AA; 124053 MW; F428E7B9881FFFF5 CRC64;
MNPRDTVEVM ETQAGDQKEK LSGDKSNPGN EIEGEDDKIP GAYDCNICGR SFPFLSSLSQ
HMRRHTGARP YKCPYCDHRA SQKGNLKVHI RSHKLGTLSS HHSNEDEEGG AEEEEMRVSE
GLDGGTSPTK SSSACNRMIN GDGGEESRRK VPARSMKREK SVTDQRPYCC RLCGYEAQRE
DQLLSHIEKV HITADTEEET TVKEEAVTEP DSSLIQPQSD GTFPCETCGQ VFTQAWFLKS
HMKKHAGILD HCCRICGRRF REAWFLKSHM KTHNTKSRSR SKADSAEHPA TINDVAQDPD
IVTVSVTSIY QMCSKCGNLF HSRESLRAHD KVHSLRYDRK SPNQCRPIED EDSPAAKRRF
LDCLNLQPVE GKTLDEEEEN EKKILGQRIP ELDPVCSYQA WQLATKGRVV EPVEPTYKAS
QAGGSMGEEA LAGAAVVFEK ESSRYVLKGQ EKRSSGRRSS YGLGSHNASG DRTPESLSDS
EYRPSSRQDR RRPSQSQAST KSNECFECGK VFRSRHQMVV HQRVHRKDGG RVSVGDKERT
ARDDRWGSTS DPESGSPSRP STPGYGDSPP ASTLGDQASE MGSSNSGEPA DEKPYICSLC
DFVTTESQAY LGHVHIQHNS KDKPSPIPSP SSNLDRSTPS GYPKLKKALL QGLNNSASPP
TYLSARSTAL DPSMTPVDLC VRAEGIRGIA SSALDRKNLP SHKCSFCAHS TRYPEVLWMH
QTVAHRINSS SSNLAPKWAL KNNSKGSRDS LLSSRRRTGP PPVLDGKECQ PLPPLMRTQR
TRPPACSTEV PKKNKPASHA ATPSSSSSTP CSSSSRGSSS TSGNQAGRVP VRPGSSTSSS
VRHIEDQSHQ SRFRPKVDMY PRASSLSSSS SMEKNTGSLS RSSAPSPSSA APSRMDRYLM
PQEGLGFMLS SKHGLAEYSR ARGSLHQPLP NSHSQVRTNT TRPSAITYSS AAAHNYGASQ
AQGGTLQNSS SPSSSSSLPS EARGDVKHEP ITETPEMPTD ILTFLKNYSP HELAALYHRW
GAANALLDPT GMLRSLMRQG QYFCHECGKS FSQPSHLRTH MRSHTGERPF CCQLCPYRAS
QKGNLKTHVQ SVHHLPFDNS QYLDTRTLLL SQEERGALAA KHPPNSQQ
//
