ID A0A3Q1EIG6_9TELE Unreviewed; 1821 AA.
AC A0A3Q1EIG6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000003279.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000003279.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR STRING; 80966.ENSAPOP00000003279; -.
DR Ensembl; ENSAPOT00000012014.1; ENSAPOP00000003279.1; ENSAPOG00000000125.1.
DR GeneTree; ENSGT00940000166169; -.
DR InParanoid; A0A3Q1EIG6; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF2; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 2.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 77..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 820..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 863..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 907..940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1031..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1110..1130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1142..1161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1245..1263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1337..1360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1494..1528
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1519..1538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 312
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 631
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1004
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 1821 AA; 205101 MW; FEC1168282AE718D CRC64;
RQQAGGGQQN GPQPLNAPPG GDAGKSDTLG STGSSRKRGG GAKKAMQANK SALRAPRALC
CLTLSNPIPL TTVFKPFDIF ILLAIFANCV AMGVTKPYPD DDSNATNHQL EQVEYVFLVI
FTIETFTKIL AYGLVMHPSA YIRSGWNLLD FIIVIVGLFS VIAEGMTDHK PGEAHHAAGK
PGGLDVKALR AFRVLRPLRL VSGVPSLQIV LNSIMKAMVP LLHIGMLVMF VIIIYAIIGL
ELFIGRMHKT CYFVSLMVED DPSPCAFAGS GRFCVGNGSE CRGKWEGPNG GITNFDNIFF
AMLTVFQCIT MEGWTDVLYW MNDAIGYEIP WIYFVSLVIF GSFFIINLVL GVLSGEFSKE
REKAVARGEL QKAQESKQME EDMIGYMDWL IEAEDVDEEG NKRYQNFCVC STESDSDDDI
AYLDDDNGFC LCQLNHTFRK NCRVAVKTTN FYWLVLLLVF LNTVASASEH YGQPKWLTEM
QERANKILLL LFTLEMLMKM YAFGLQIYFM ALFNRFDCFV VCGGILETLL VEFDVIPPIG
ISVLRCIRLL RIFKMTRHWA ALSDLVNSLL NSMKAICSLL LLLFLFLIIF ALLGMQLFGG
KFNFDETQMK RSTFDSFPQA LLTCFQILTG EDWNAVMYDG IMAYGGPIFP NMVVCIYFVI
LFVCGNYILL NVFLAIAVDN LAGDAFGDKL VFLFAAAFTP ISYFYSNILT VYSERKRKRK
KSGMRMKRKR MKMQGRLTCL LFVVGVAPLK PDFSGPKEKI VPIPDGSSFF ILGKKNCLRV
ACHNLIHHPY FTNFILIFII LSSISLAAED PIKSHSFRNI VLGYADYVFT SVFTVEIVLK
MTVYGAFLHT GSFCRNAFNL LDLLVVSVSL TSFFLHSSAI SVVKILRVLR VLRPLRAINR
AKGLKNVVQC VFVAIRTIGN ILIVTTLLQF MFACIGVQLF KGRFYSCTDE AKHTPYECKG
TFVVYKDGDM NHPMVRERIW QNSDFNFDNV LMGMLALFTV STFEGWPQLL YRAVDANAIN
RGPIYNYRVE ISIFFIIYII IIAFFMMNIF VGFVIITFRE QGEAEFKNCE LNKNQRQCVY
YALKAQPIKI YIPKNPSQLK FWKIINSSQF EYVMFVLILG NTLTLAVQHY EQSKLFTSIM
DILNMIFTVV FTIEMIIKLL ALRAHHYFID PWNSFDALIV VGSVLDIAVS EFSGGGGHGE
VRTDQSGKVS ITFFRLFRVL RLVKLLSKGE GIRTLLWTFV KSLQALPYVG LLIAMIFFIY
AVIGMQTFGK VAVDDDTHIN RNCNFQTFFM AVLVLFRCAT GEQWQEIMLA ALPGRRCDPE
SDTEPGEEFS CGSNLSYIYF ISFFMLCAYL IINLFIAVIM DNFEYLTRDW TVLGTHHLDE
FKRVWSDYDP EATGRIKHID VVTMLRRIQP PLGFGKLCPH RVACKRLVAM NVPLHADGTV
TFNATLFALV RTSLKIKTEG PIDQQNEELK VIIKKLWKRT KPKLIDEVIP PPRGDEVTSG
KFYASFLIQD YFKKFRKRKE RERKSKRKDK AASLQQGLRT LQDLAPEMRL AMACDLEEEE
ATEGEMTADE IFDSGTSANT TPASTPMPRL DMLVEQTTVI VEPEPKISNG DVITEQVTGL
QEHQKPGSDL AGLNIVTEQP VRSELTVLHL AQFSNTSTCF LFSGRKPAFN FQCLRPQSSV
DDLPIPGTYH GNTSPSRSRL QVEQRGKLIY TPMILVDEAT GTSQPLTFTS VRMPPPVNQG
LVNKGSADSL VESILISEGL GVYARDPKFV NFAKREIAEA CHMSLDDMES AAADLIARGA
SQSISRFEDE LADEMNCVIS Y
//
