ID A0A3Q1EIL5_9TELE Unreviewed; 1024 AA.
AC A0A3Q1EIL5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Integrin subunit alpha 8 {ECO:0000313|Ensembl:ENSAPOP00000003349.1};
GN Name=ITGA8 {ECO:0000313|Ensembl:ENSAPOP00000003349.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000003349.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000003349.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3Q1EIL5; -.
DR Ensembl; ENSAPOT00000011892.1; ENSAPOP00000003349.1; ENSAPOG00000004971.1.
DR GeneTree; ENSGT00940000156737; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF5; INTEGRIN ALPHA-8; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 3.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 972..994
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 41..108
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 123..184
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 189..241
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 274..338
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 339..397
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 449..604
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 605..745
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 751..961
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1024 AA; 112715 MW; 4F2BC5C15CA375B0 CRC64;
MDQTKEDSTS RAQDCVSSAG MFILGLLYVL WPALSGVWSF NFYAEHPTVY RGPDGSYFGY
SVDFYQATAD SNMISVLVGA PKANTSQPGI MEAGAVYYCP WPGKPESCRQ IPFDNSSEMI
KVNGTREPLE FKSHQWFGAS VRTHKGKVVA CAPLYHWRTV KVSGEKDPVG TCYVAVQNFS
AYAEYSPCRT NDPDPEGQGF CQAGFSVDFT KEGRLVVGGP GSFYWQGQVM TAGIAEILNG
YSLKAVLRQV PGEKHTRAAE DTHDDSYLGN MHFQILTQRN EGMASYFGYS VAVTDLNGDG
TDDVLVGAPL FMEREMESKP REVGRVYLYL QLAPLTFSEP VALTGTYTFG RFGTAIAPVG
DVNQDGYNDV AVGCPFGGDD RGGRVLIFNG NRDVSAQGLM LSQELRAASS PGSSLPGFGF
TLRGGQDVDN NQYPVCSAHA FVWVCACRAQ AVVSVEASMI LTPRILNPED RQCHLPQMNT
MVTCLKVNVC AAVSGVGIPS SVDLRAELHL DWLKGSRGGV KRVLFLDTQQ PQHTGLLRLG
HNRPRACLSY MIYLKDDEFR DKLTPISLAL NYSLAPPPQD QNLPPVLNHY SSTFLQEHAY
ILLDCGDDNI CIPDLQLSAS MDRTELVIGD DNLVMLTITA VNRGEGAYET ELHALIPPEA
DYIGVQRRVE SLSELNCEYK MINESRMVVC DLGNPMVAGT ELAVGLRFSV QRLKDSGPKI
SFELQIHSSN KDNPDSNLVS LNLSIVAQAR LDLRGVSHPS QVVLPFPNWE PKEKPVKEDE
VGPQVTHIYE LHNSGPSSIG EAELQVGWPS RFRDENLLYA MDIQTDGPIS CRTNTSLNPH
GLQISNVQDT PELLGFLRNI SAPPHRHKRS VSTAQSYSSK TLNCTNISCL KIMCVVGRLD
RGQSAVVKIR SRLWAHTFLQ RRNDPYILNS TVSFMVLSMP YRIQPATLPH HKTSMGTLVL
WGTPDVSFAV PLWVIILAIL LGLLVLAMLT LAMWKCGFFD RARPPADDDI SDQEQLTSDQ
TGDA
//
