ID A0A3Q1EK49_9TELE Unreviewed; 1075 AA.
AC A0A3Q1EK49;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Integrin subunit alpha 3 {ECO:0000313|Ensembl:ENSAPOP00000004856.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000004856.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000004856.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3Q1EK49; -.
DR STRING; 80966.ENSAPOP00000004856; -.
DR Ensembl; ENSAPOT00000009308.1; ENSAPOP00000004856.1; ENSAPOG00000006569.1.
DR GeneTree; ENSGT00940000157746; -.
DR InParanoid; A0A3Q1EK49; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0033334; P:fin morphogenesis; IEA:Ensembl.
DR GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0060297; P:regulation of sarcomere organization; IEA:Ensembl.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF89; INTEGRIN ALPHA-3; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 23..1075
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5018380823"
FT TRANSMEM 995..1019
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 27..93
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 287..348
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 349..404
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 452..608
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 609..756
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 768..984
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1075 AA; 120269 MW; E19F8358ECA8FE8B CRC64;
MSPRLLFCAL LCVYHGTQTC SGFNIDERFP VIKEGKTKGS LFGFSVALHQ QTEGSKKYLL
LAGAPKEKAQ SLKNVNETGA VYSCPVTTDS TDCSRMDLVS KTNPSEMVEG MWLGVTVASQ
RGQLAGRVLA CGHRYVKIMQ GGTEEQRRMI GKCFVRSNDL SYDSNDEWQT HSYEFCNPGL
DMEFEGMCNM GISGGMTETD VYVGAAGSYL WQGNVHVTWR NPEDGYEWDS ADKGFGQLKK
RYSYMGYSVL EEQKLLSLDD YTVVTGAPRY ESKGSVMFGR KAVTNIELVQ ILPGEQVGSY
FGNSLAVTDL NNDNWNDLIV GAPFYFDRMK DQGGAVYIFM NENGSFQNKS TVVLKGPSDS
GFGIAVAAIG DVNQDGFQDF AVGAPFHDTG KVYIWMGSKK GISMEPSQVI EGKSLGFQTL
GYSINGGMDM DDNSYPDMLV GSLDNRIALL RARPVVHLTK DFKVKPKIVD PNKCPGNTPC
ITATLCMSFT LSNGNKEFKK DIMVKYTVEA DMERRRSPRV RFQANNDDTY TDILSLSSSS
SKPKCHDIKL FVVGPVRDKL EPVVFSLNIS LQEQKTKARR SVQNLDSFPI LSQEQKLTQR
TEINFQKECG SDNKCSSNLQ MTAQFVDNKE HPYPRKGSFQ VLQFNSNVKL VTLQVEVTNF
PSAGKLAEDA HQAELNVTIP DALKYSAVRS EDRDVRCELD VTLICDLGNP FKGNEKVSLQ
LKFETSGINL YTEMIESQLL LSTLSEQSDL QPVPVAMLIE NTILPTFSIT KQLVQTKFGG
TVMGESAMVN TSDVGSLVEF TFNVDMKGQL LGDMGTMAVE FEWPYEVANG KWLLYLTKIL
VRGQSEMECN PAGEVVNELN LTLSESPPKR TKRQIAVDDP DDPTRPHIIE PQAAITLLTP
RKESYLLECS KGTAKCVTFT CPILNMTNSA EIYVQSRLWN STMLEDYANA LRVIVKGQAT
LKLITDKPTL KMDSQTTTFT VEIEPVEGVE IPYELPLWII ISAVVAGILL LGIIIFILWK
LGFFKRAIYY RIMPKHQGVK IRRAERYQFN LGFQPEEPQK KYWITNWTEM QHYYY
//
