ID A0A3Q1EKK7_9TELE Unreviewed; 1271 AA.
AC A0A3Q1EKK7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=DENN domain-containing protein 5B-like {ECO:0000313|Ensembl:ENSAPOP00000003842.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000003842.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000003842.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR AlphaFoldDB; A0A3Q1EKK7; -.
DR STRING; 80966.ENSAPOP00000003842; -.
DR Ensembl; ENSAPOT00000011063.1; ENSAPOP00000003842.1; ENSAPOG00000005377.1.
DR GeneTree; ENSGT00940000153678; -.
DR InParanoid; A0A3Q1EKK7; -.
DR OrthoDB; 5398783at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17677; RUN1_DENND5; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070:SF3; DENN DOMAIN-CONTAINING PROTEIN 5B; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 31..585
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 772..932
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 934..1042
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1115..1266
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 138..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1271 AA; 141494 MW; 33307FDAAE644D05 CRC64;
MNGTGAGSAS CRFAHYFVVC GVDTETGLEP DDGAGEGFEQ SPIRRSFKSK VLVHYPENTD
RNPFNKDAVN MLCMPRGLSF RTQADRLDPQ FHSFTIAFDD GTRSYGFVHT FYEEVTSPQI
ITAMQTLYQM HHVEHHSSSS ASSPSCSSSS SASSPSTSSM DSLASSLDES DAESLAGVPG
CLGCAGSFDP ARDTLYVSKA LCLVTPLPFL QASRQFLAQL HQAVTSQTAP PLPLESYIHN
ILYEVPLPPP GRSLRFHGVQ GPIVCQRPGP GELPLGEFLL GDSFSLLGVD NMVKLLTCAL
LETQVLLYSQ DYQRLMTVAE GITTLLFPFQ WQHIYLPIVS TPLHHLLDAP VPFLMGIQRR
DGAQRSSLHL PHEANLCFVD IDNHCVEAPE DLPLFPDQTE LIQELSEVLL HFGLPPQGGA
ITKPTTTSSS SSSSPSPRLS SLVLEDLMED RRNGNLGGEE LAVLERLQAL ARRCGGGKMS
DGGKTLGHVF EEEEEELKAA KLNIQLREVF AVRFAAMFGR YEEFVIHSAL DLDSWLSNRE
GTFSFDKGSF LSVQPAAHLH FLSRFLETSM FSSFVDGKVI SRWADKEPLQ LLFDSRLERE
RLYDTGEEDP RSCPYRKCTT LFESAHNIER RLLKADHTAI HPHLLDMRIG QGRHHPGYFP
KLQADVLAQA QNTNKWSSRV TTSSRRSEPK RSTVNDHSGV DNELRQKHTY TRKLLRQSKL
LDPSPQAVTQ THREFVDGLL SECRLKTKRM LMERMGKESV ELGQGEANIT GLQENTLIHG
LCDLLERTWG HGLQMKQGKS ALWSHLLHYQ AAQGKTEAPS DSPGSNCSDQ RTLDDGTLPL
RGSLMQDMRF IQTMSEGLSE VGQARAWIHL ALEKKMLSQH LKELLTNQEL LRQLYKPHAF
LLCEEEREQF LFHLLSLNTV DYLCFTRVFT SICIPYRVVI IPMKKLSIAM ATVNPWVCVS
GELGDSGVRQ IPKNTQEIFF QCKNLGRLST LQLGQENSGL LAKCLIDCVM VYNEITGHTY
KFPCGRWLGK GVGDGSLERV LIGQLVSPGA EEDAGRWTGT PPELASPSQS VRMVLGSLGS
RSRMLSVEVQ EDMREAANNL VKHFHKPEQE RGNLTVLLCG EGGLVLSLEK FLLHGFKSNR
LFQRNVFVWD FVEKAVVSME TADQMGDLHG STLTRGPPCD SLCRYVNAIN ASTRNIGKEG
KFQLFVCLGI RDRLLSQWLP LLADCPLTAR TYEDGALLRD RAAVHSLSRI VHTLNEFSIT
LETALVKGVD L
//
