ID   A0A3Q1EKU5_9TELE        Unreviewed;       685 AA.
AC   A0A3Q1EKU5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Discs large MAGUK scaffold protein 4 {ECO:0000313|Ensembl:ENSAPOP00000004418.1};
GN   Name=DLG4 {ECO:0000313|Ensembl:ENSAPOP00000004418.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000004418.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000004418.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q1EKU5; -.
DR   Ensembl; ENSAPOT00000010075.1; ENSAPOP00000004418.1; ENSAPOG00000006156.1.
DR   GeneTree; ENSGT00940000157956; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF33; DISKS LARGE HOMOLOG 4; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 2.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          47..137
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          145..232
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          296..377
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          411..481
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          495..670
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
SQ   SEQUENCE   685 AA;  76435 MW;  1E348131C52E0D65 CRC64;
     MFMSVWYAKK MGCRFLNNVR KAKKHRHHRM VGMLLCLLYM FDHDNTSAYL EKSLLGNSGL
     GFSIAGGTDN PHVGDDPSIF ITKIIPGGAA AQDGRLSVND CILFVNDVDV REVTHSQAVE
     ALKEAGAIVR LYVLRRKPAA EKVTEIKLIK GPKGLGFSIA GGVGNQHIPG DNSIYVTKII
     EGGAAHKDGR LQIGDKILAV NNVCLEDVMH EDAVGALKNT AEVVYLRVAK PNNLFLTNSY
     NPPDLTTYSH MDTELSHPNY LGSDYPQALT PTSPSRFSPV LHGIMGDDDI PREPRRVLIH
     RGSTGLGFNI VGGEDGEGIF ISFILAGGPA DLSGELHKGD QILSVNGVDL RMATHEQAAA
     ALKNAGQTVT IIAQYRPDEY SRFEAKIHDL REQLMNSSMG SGTTTLRSNP KRGFYIRALF
     DYDKTADCGF LSQALGFKFG DVLHVLDCGD EEWWQARKVS PQNEAEEVGF IPSKHRVERK
     EWSRVNTKER VLHYARPIII LGPVKDRIND DLLSEFPDKF GSCVPHTTRP KREYEVDGRD
     YHFVSSREQM EKDIQSHRFI EAGQYNSHLY GTSVQSVREV AEQGKHCILD VSANAVRRLQ
     AAQLHPIAIF VRPKSLENVL EINTRLTEEQ ARKGMDRALK LEQDFLECFS AVVEGDSFEE
     VYHKVKTVIE EQSGPYIWIP TRERL
//