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Database: UniProt
Entry: A0A3Q1EPZ2_9TELE
LinkDB: A0A3Q1EPZ2_9TELE
Original site: A0A3Q1EPZ2_9TELE 
ID   A0A3Q1EPZ2_9TELE        Unreviewed;       416 AA.
AC   A0A3Q1EPZ2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Tyrosine 3-monooxygenase-like {ECO:0000313|Ensembl:ENSAPOP00000006018.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000006018.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000006018.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954,
CC         ECO:0000256|PIRSR:PIRSR601273-2};
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR   AlphaFoldDB; A0A3Q1EPZ2; -.
DR   Ensembl; ENSAPOT00000007365.1; ENSAPOP00000006018.1; ENSAPOG00000007918.1.
DR   GeneTree; ENSGT00950000182885; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 2.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR   InterPro; IPR036951; ArAA_hydroxylase_sf.
DR   InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   InterPro; IPR049321; TH_ACT.
DR   InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR   PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR   PANTHER; PTHR11473:SF38; TYROSINE HYDROXYLASE 2; 1.
DR   Pfam; PF00351; Biopterin_H; 2.
DR   Pfam; PF21417; TH_ACT; 1.
DR   PIRSF; PIRSF000336; TH; 2.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR   PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR   PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 2.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000336-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR000336-1};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT   DOMAIN          97..161
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   DOMAIN          192..414
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   BINDING         247
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT   BINDING         252
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT   BINDING         292
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
SQ   SEQUENCE   416 AA;  47000 MW;  27DCB3E4E77A0F2F CRC64;
     DGGSSGSPGP SRYGDGFVFE EKQGRVIVNV LFALTGGKNA GFFKTGKIFE TFEAKLLHIE
     SRPGRKLKNS TTDLEFFMKC EVHSSDLDVF INSLKRVADD VRSIPEENVP WFPRQIKDLD
     RCNMLITKFD PDMDQDHPGY NDSEYRKRRA AISELAFRYK HTPHDPSEDK TVCCTNKPAL
     FNYRSTLNTT CLSSVPSEKT GFQLRPVAGL LSARDFLASL AFRVFQCTQY IRHSSAPMHS
     PEPDCCHELL GHIPMLADKE FAQFSQEIGL ASLGASDEDI EKLSTLYWFT VEFGLCKQNG
     AVKAYGAGLL SSYGELVYAL SNEPEYKPFN PEETAVQPYQ DQTYQPIYFV SESFEDAKIK
     LRKYSANIKR PFAVRYDPFT CSVEVLDQPR KIQNALSQMR EDLKTLHSAL EKLSSS
//
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