ID A0A3Q1EPZ2_9TELE Unreviewed; 416 AA.
AC A0A3Q1EPZ2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Tyrosine 3-monooxygenase-like {ECO:0000313|Ensembl:ENSAPOP00000006018.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000006018.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000006018.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR AlphaFoldDB; A0A3Q1EPZ2; -.
DR Ensembl; ENSAPOT00000007365.1; ENSAPOP00000006018.1; ENSAPOG00000007918.1.
DR GeneTree; ENSGT00950000182885; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 2.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR InterPro; IPR049321; TH_ACT.
DR InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF38; TYROSINE HYDROXYLASE 2; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR Pfam; PF21417; TH_ACT; 1.
DR PIRSF; PIRSF000336; TH; 2.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 2.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR000336-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR000336-1};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT DOMAIN 97..161
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT DOMAIN 192..414
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 247
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 252
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
FT BINDING 292
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR000336-1"
SQ SEQUENCE 416 AA; 47000 MW; 27DCB3E4E77A0F2F CRC64;
DGGSSGSPGP SRYGDGFVFE EKQGRVIVNV LFALTGGKNA GFFKTGKIFE TFEAKLLHIE
SRPGRKLKNS TTDLEFFMKC EVHSSDLDVF INSLKRVADD VRSIPEENVP WFPRQIKDLD
RCNMLITKFD PDMDQDHPGY NDSEYRKRRA AISELAFRYK HTPHDPSEDK TVCCTNKPAL
FNYRSTLNTT CLSSVPSEKT GFQLRPVAGL LSARDFLASL AFRVFQCTQY IRHSSAPMHS
PEPDCCHELL GHIPMLADKE FAQFSQEIGL ASLGASDEDI EKLSTLYWFT VEFGLCKQNG
AVKAYGAGLL SSYGELVYAL SNEPEYKPFN PEETAVQPYQ DQTYQPIYFV SESFEDAKIK
LRKYSANIKR PFAVRYDPFT CSVEVLDQPR KIQNALSQMR EDLKTLHSAL EKLSSS
//