ID A0A3Q1ERP6_9TELE Unreviewed; 2227 AA.
AC A0A3Q1ERP6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Desmoplakin b {ECO:0000313|Ensembl:ENSAPOP00000006664.1};
GN Name=DSP {ECO:0000313|Ensembl:ENSAPOP00000006664.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000006664.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000006664.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 80966.ENSAPOP00000006664; -.
DR Ensembl; ENSAPOT00000006262.1; ENSAPOP00000006664.1; ENSAPOG00000008615.1.
DR GeneTree; ENSGT00940000154843; -.
DR InParanoid; A0A3Q1ERP6; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0030057; C:desmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002934; P:desmosome organization; IEA:Ensembl.
DR GO; GO:0061436; P:establishment of skin barrier; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 3.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR PANTHER; PTHR23169:SF26; DESMOPLAKIN; 1.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF00681; Plectin; 6.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00250; PLEC; 16.
DR SUPFAM; SSF75399; Plakin repeat; 4.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 23..61
FT /note="Desmoplakin SH3"
FT /evidence="ECO:0000259|Pfam:PF17902"
FT DOMAIN 96..173
FT /note="Desmoplakin spectrin-like"
FT /evidence="ECO:0000259|Pfam:PF18373"
FT REGION 1896..1933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2173..2227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 557..728
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 762..856
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 902..978
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1007..1111
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1144..1255
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2227 AA; 253453 MW; EAD04BE6520068FB CRC64;
MWRYYFTTSF VFKITFHWAP QKVICKDNEA ILKDNSQRSK WQVTGPGGLD MLVPSVCLIV
PPPNPLSISL ANKNEQYYEA ILSIWNQLYI NVKSLIAWQY CLLDIRRINS LTINMLAKMR
PEEYRQIIKS LETHYEEFKL SSRGSQMFAD EDKRSIENQF TGAQAHYDQL VVQLPTYGQR
VSSSSVSTAS SSSHSLSELH SLRLRLEAAE SMLSQHLHVC VGEDAVHDCG LKISQLEMVQ
RDVDAMRDEY LSLRERILRE LEGMNDSDKA QFLRSEVGVI NQRLGSLESS SSAYVQRLRA
LRDMLESVAR AEDIVKVHEA RLTEKETTSL SPGEVDEYML TLKVFSELDQ KKDVMSSMEK
ELTKASHWNS QVGDPFHRCD MMLSKYTEEV GVLSDRWRRI QGQIDTRLQD LQLYVPQLQH
YKQTSTSLFD WIDATTKKQN ALQATKIENV QALKDHITNQ KALNTEIKAK RETVERVLKD
NEACVNAIKD YETDLSSYTS GLETLLNVPI KRTMLKSPSM DLNQEAIQLQ TRYMELLTMS
GDYHKFLGES LKNMEELKIR DTRIDLLEEE LRLLREDIQD CNGRNKSLED TVARYQLELS
QSQEQLLSVE EVKRNTALQC NATKESLDST QSQLTELSDQ VTRLKYLLDE EKRKRKLAEE
RYNQQQEEYE SVLRKRQNEL ETVSWSKMDV EKSVANKDHE IENLRRQLDA ETGRVKELQT
DISKVRSQCN MEINSLKLSY ESQIQASRTD IHRLAAQRDE DTAELHMQYD RMEAERRSLE
EEVKKLRISV VQAEEQRMRS EEEAQSQRAL IIEEGRRRRE LESQVELLMS QRDEESSEYR
EELAELLKTL QDKSDQLAYV THSLEEENRR RKTIEEGQAV LKQTVNQLQV KLASSSVATT
QLREYDEELQ KMRLELERES KERSRMEQNM SRLNSRIKDL QAVRDGLESQ MENLRIANQE
EVARRRQAEA ELEKTTINMT EYATTITALR KSQEQASTSG KRGEEERLRL QEELERSLRQ
NKNSAERMTQ LSTELKALQQ QLLQEQAYLK EAKLRNDGLY RTIEEKSKAL NENTVQLESL
KEITETQTKE RLRLEEELRA AHHDKEELLR SKQGRDDELS TQITTLELQL QASERSNKDY
HSLVSELSSE REKLKLETEN MQTQATETRA MMQSLQSQYN DVVKERDAEL RNKQRLQEEN
ERVKRDLSYW KDQCDSKQGM IRQYDTDKEI LERDKKSLKS EIERLMRELK DLDETNKSRL
SSIQREMKEV SVRQTKETEL KTTRAPPILE TSTAIFDGVR KPVTANQLLD CGVLDKPTFN
QLMKGHKTVP EVSVDKKVNL KGTGPIAGVV IESPKSPGSM TRTLCKMTFT EAKKDNLLPQ
DSVDLLLDAQ AATGHIIDPR TNQKLTVEEA CNQGVVDDED RERLLAAEAA AVGFGGPGTS
KPLSVFQAMK KGLIDKTTTL RLLQAQEATG GILDPINSVF LPKDTIAKER DLIDEDLSHA
LNQSPECYLD PDTQQTTTYV SLKKKCKVDP STGLLLFPEP KKTVTVKGIR NQVSVIDLVD
ANLLKQSDVD QLREGRLTNQ EIEDRLSSYL GGSTCIAGVY DEASDKVLPI YQAMKEELLS
RGIAVQLLEA QAASGFIVDP LNNLYLTVSD AYNRGLFGPE FKDKLLAAEM AVTGYKLPGT
DSILSLFQAI ERGLVERGQG LRLLQAQIAS GGIIDPKHGH RLDANIANKR GYCDDKMNNI
LANEKGFFDP NTEEDLTYLE LKKRCKTDKK TGLILLPINE KTKQRSVQKN TRGKRRVVIV
DPETNEDMTV REAFNKGYID YLTFIELSKQ ECEWEEVTST DPDGSSQCVV IDRKTGREYN
ITELLKKQVI SQSVFQQYRS QTMTLTQFAD FITKKTEHGS PSLSSSSLSS STTSRPSAAS
LTSSTLRTSE VTTTKTTTIT ERGSTISTGV RDSPDSFKHI SSVSVHLETP DEIVGEQEPV
GAIFDTDNVE KISITEALNR DLVDSITAQR LLEAQACTGG IVNPANGQRL SIQEASRMGL
IDDDMATKLK PAQKAFIGFE DVKTRKKMSA AQALKERWLP YEAGQRFMEF QVATGGLYDP
EVGCRRTIED ALKMGWLDVR AAQKLQDMKH HAKLLTCPKS KLNISYKDAL DNCLVEESTG
VKILQASSVS SRGISSPYNV ASAPGSTTGS RSGSRRSSRR ASLDLGSPTS SSTSRYNPTN
VTYFPFQ
//
