ID A0A3Q1ETP4_9TELE Unreviewed; 1350 AA.
AC A0A3Q1ETP4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRK {ECO:0000313|Ensembl:ENSAPOP00000007414.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000007414.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000007414.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR Ensembl; ENSAPOT00000004992.1; ENSAPOP00000007414.1; ENSAPOG00000009537.1.
DR GeneTree; ENSGT00940000156249; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF11; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 665..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..107
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 109..194
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 207..302
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 407..508
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 800..1052
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 972..1043
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1084..1346
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1260..1337
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1350 AA; 151715 MW; B0FDA52D07C2C551 CRC64;
HQEMADIWNF NLSAGLINSY IADSNKHKNM SFQLTIPLNL SVNKGPLANP IWNVTSYTGK
DWLRAELAVS TFWPNEYQVI FEAEISDSKA GFIAIDDIQV LSYPCDKSPH FLRLGDVEVN
AGQNATFQCI ATGRDTSNNK LWLQRRNGED IPVALTKNIN HRRFAASFHL KEVTNQDQDL
YRCVTQSERG SGVSNFAGLI VREPPHPIAP PQLLGVGPTY LLIQLNANSI FGDGPIILKE
VEYRMTSGSW TETHAVNSPN YKLWHLDPDT EYEIRVLLTR PGEGGTGKPG PPLITRTKCA
EPMRTPKRLK IAETRSRLIA VDWESLGYNI TRCHTFNVTI CYHYTTANNH SKADCLDMDP
KAPRHLVGNL PPYTNVSLKM ILTNPEGRKE SDETIIQTDE DVPGAVPSQS LRATPSEETI
SLYWKEPAEP NGVIIQYEIS YSGVRSFDPS VPLQRPGLTV SLPSNATHHM FSQLHPGVTY
LLSIRASTSK GFGPATMLNV TTNISAPTID EYDGSEAFLN ETATTITVLL KPAQAKGAPI
SAYQIVVEEV NPQRTRRQAS SDCYEVPVSY HSASSGGSPY YYAAQLSPSN LPEPLPFTVG
DNKTYQGFWN PPLAPRKNYN IYLQAVSSTE RETKTQCLRL AAKRATEEPE VIPDPAKQTD
RVVKIAGISA GVLVFILLVL VAILLVKKRK LAKKRKDAIG TTRQEMTHMV NAMDRSYADQ
STLHGEDPMA VTFMDSHNYN NRYENHSGSA AENSRLLDVP RYHCEGTESP YQTGQLHPAI
RVADLLQHIN LMKTSDSYGF KEEYESFFEG QSASWDVAKK EQNRTKNRYG NIIAYDHSRV
ILQPIEDDPS SDYINANYID VSGNASNATI GPVHETVYDF WRMVWQEQSA CIVMVTNLVE
VGRVKCYKYW PDDAEVYGDF KVTFVEVEPL AEYVVRTFTL ERRGFNEVRE VKQFHFTGWP
DHGVPYHATG LLSFIRRVKI SNPPSAGPIV VHCSAGAGRT GCFIVIDIML DMAEREGVVD
IYNCVKALRS RRINMVQTEE QYIFIHDAIL EACLCGETAI PVCEFKAAFY ELIRIDSQTN
SSHLKDEFQT LNSVTPQPQP EDCSIALLPR NQDKNRFMDG LPPDRCLPFL ITIDGESSNY
INAALMDSYR QPAAFIVTQH PLPNTVKDFW RLVYDYGCTS LVMLNEIDLA QGCPQYWPEE
GMLRYGPVQV ECMSCSMDCD VISRLFRVCN LTRPQEGYLM VRQFQYLGWA GHREVPASKR
SFLKLILQVD QWQREGEEGE GRTIVHCLNG GGRSGVFCAS SIVCEMAKRQ SVVDVFHAVK
TLRNSKPNMV DTPEQYRFCY DLALEFIESS
//